PAR-22-250: Centers of Biomedical Research Excellence (COBRE) Phase 1 (P20 - Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants of up to $1.5 million to state and local governments. Applications closed on January 30, 2025.
From the official notice on Grants.gov, last changed September 21, 2022. Checked November 7, 2026.
- Award ceiling$1.5 million
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeP20
- Clinical trialsOptional
- Funded byNIGMS
- Median yearly award$300,000
- Typical project length5 years
- P20, Exploratory Grant. Planning or building a research center or program. Other open P20 notices.
Projects funded under PAR-22-250 were run by National Institute of General Medical Sciences (NIGMS, 27 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-22-250 in the NIH Guide.
Key dates
| Posted | September 14, 2022 |
|---|---|
| Deadline | January 30, 2025 |
| Archived by Grants.gov | March 7, 2025 |
Who can apply
This opportunity was open to state and local governments.
- State governments
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $300,000; it allows up to $1.5 million per award.
- Most of the program's money (80% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The National Institute of General Medical Sciences (NIGMS) invites applications for renewal of eligible Centers of Biomedical Research Excellence (COBRE) grants. The objective of the COBRE initiative is to strengthen an institution's biomedical research infrastructure through the establishment of a thematic, multi-disciplinary center and to enhance the ability of investigators to compete independently for NIH individual research grants or other external peer-reviewed support. COBRE awards are supported through the Institutional Development Award (IDeA) Program, which aims to foster health-related research by increasing the competitiveness of investigators at institutions located in states with historically low aggregate success rates for grant awards from the NIH. The goal of this FOA is to support existing COBRE Phase 1 Centers by further strengthening the research infrastructure and to continue the development and support of a critical mass of investigators with the expertise in the Center's scientific interest areas.
Funded under PAR-22-250 so far
NIH funded 27 projects under PAR-22-250 in fiscal 2024 to 2026, at 26 institutions. The median yearly award was $300,000.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| UNE Center for Cell Signaling Research | University of New England | 2026 | $2.1 million |
| Administrative & Mentoring (A&M) Core | Dartmouth-Hitchcock Clinic | 2026 | $874,270 |
| Administrative Core | MC Laughlin Research Institute | 2026 | $1.1 million |
| Administrative Core | Univ of Arkansas for Med Scis | 2026 | $1.3 million |
| Molecular Mechanism of Rnd3 Regulation in Lung Cancer | Univ of Arkansas for Med Scis | 2026 | $247,147 |
| Immunological changes associated with antibiotic use in oropharyngeal cancer | University of Puerto Rico Med Sciences | 2026 | $309,292 |
| Administrative Core | University of Nebraska Omaha | 2026 | $1.0 million |
| The Role of Selective A3 Adenosine Receptors Activation in Myocardial Protection in donation After Circulatory Death Heart Transplantion | University of Nebraska Medical Center | 2026 | $306,926 |
Who has won Biomedical Research and Research Training grants before
From fiscal 2021 to 2025, Biomedical Research and Research Training (93.859) awarded $15 billion across 11,631 grant awards, an average of $1.3 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Leland Stanford Junior University | California | 186 | $290 million |
| Regents of the University of Michigan | Michigan | 226 | $268 million |
| University of California, San Diego | California | 198 | $264 million |
| Yale Univ | Connecticut | 195 | $250 million |
| University of Wisconsin System | Wisconsin | 169 | $241 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-22-250 still open?
No. It closed on January 30, 2025.
Who can apply for Centers of Biomedical Research Excellence (COBRE) Phase 1 (P20 - Clinical Trial Optional)?
National Institutes of Health accepted applications from state and local governments. The notice adds further conditions, so read its eligibility section.
What is the deadline for Centers of Biomedical Research Excellence (COBRE) Phase 1 (P20 - Clinical Trial Optional)?
Closed January 30, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $1.5 million each.
Who has been funded under PAR-22-250?
NIH RePORTER lists 27 projects funded under PAR-22-250 in fiscal 2024 to 2026, at 26 institutions. The most were at Univ of Arkansas for Med Scis, University of New England, Dartmouth-Hitchcock Clinic.
Who has won Biomedical Research and Research Training grants before?
The largest recipients over five fiscal years were The Leland Stanford Junior University, Regents of the University of Michigan, University of California, San Diego. The program made 11,631 awards worth $15 billion in that time.
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