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PAR-21-321: Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)

Closed Closed January 7, 2026 Opportunity PAR-21-321

This grant is closed. A newer notice from the same program is open now: Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional) (PAR-25-444). Status: Due dates in the notice, expires September 25, 2028. It is in our archive of National Institutes of Health notices from 2021.

National Institutes of Health offered grants of up to $1.5 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on January 7, 2026.

From the official notice on Grants.gov, last changed April 2, 2025. Checked November 7, 2026.

About this NIH notice

Projects funded under PAR-21-321 were run by National Cancer Institute (NCI, 49 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read PAR-21-321 in the NIH Guide.

Other notices with this title

National Institutes of Health has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
PAR-26-149March 10, 2026Expected deadline January 25, 2027Forecast
PAR-25-444November 26, 2025Due dates in the notice, expires September 25, 2028Open

Key dates

PostedOctober 12, 2021
DeadlineJanuary 7, 2026
Archived by Grants.govFebruary 12, 2026

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

This Funding Opportunity Announcement (FOA) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-designated Cancer Centers. CCSGs support three types of Cancer Centers: 1) Comprehensive Cancer Centers, which demonstrate reasonable depth and breadth of research activities in each of three major areas: basic laboratory; clinical; and prevention, control and population-based research, and which have substantial transdisciplinary research that bridges these scientific areas; and 2) Clinical Cancer Centers, which are primarily focused on basic laboratory; clinical; and prevention, cancer control, and population-based research; or some combination of these areas, and 3) Basic Cancer Centers, which focus on basic laboratory research. The purpose of all types of NCI-designated Cancer Centers is to capitalize on all institutional cancer research capabilities, integrating meritorious research into a single transdisciplinary research enterprise across all institutional boundaries. Cancer Centers supported through this FOA are expected to serve as major sources of discovery of the nature of cancer and of development of more effective approaches to prevention, diagnosis, and therapy; to contribute significantly to the development of Shared Resources that support research; to collaborate and coordinate their research efforts with other NCI-funded programs and investigators; and to disseminate research findings for the benefit of the community.

Category: Health.

Funded under PAR-21-321 so far

NIH funded 49 projects under PAR-21-321 in fiscal 2023 to 2026, at 49 institutions. The median yearly award was $178,788.

Recently funded projects
ProjectInstitutionFiscal yearAward
Cancer Center Administration P30Rutgers Biomedical and Health Sciences2026$269,143
Cancer Center Support Grant P30University of Minnesota2026$4.1 million
Cancer Center Support Grant P30University of Chicago2026$4.6 million
Stephenson Cancer Center - Cancer Center Support Grant P30University of Oklahoma HLTH Sciences Ctr2026$2.0 million
Cancer Center Administration P30Ohio State University2026$359,168
Leadership, Planning and Evaluation (LP&E) P30University of California Los Angeles2026$908,500
Cancer Genomics and Epigenomics P30Case Western Reserve University2026$56,914
Cancer Research Training and Education Coordination (CRTEC) P30Salk Institute for Biological Studies2026$252,398

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Human Genome Research grants before

From fiscal 2021 to 2025, Human Genome Research (93.172) awarded $2.2 billion across 1,255 grant awards, an average of $1.7 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Leland Stanford Junior UniversityCalifornia59$153 million
University of WashingtonWashington46$123 million
The Broad Institute, IncMassachusetts22$119 million
University of California Santa CruzCalifornia17$64.7 million
Baylor College of MedicineTexas24$62.9 million

Top states: California ($470 million), Massachusetts ($350 million), New York ($193 million), Washington ($145 million), North Carolina ($119 million).

Applying now

This notice no longer takes applications. Apply under the newer notice, PAR-25-444, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is PAR-21-321 still open?

No. It closed on January 7, 2026. A newer notice is open: PAR-25-444, due dates in the notice, expires September 25, 2028.

Who can apply for Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)?

Closed January 7, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $1.5 million each.

Who has been funded under PAR-21-321?

NIH RePORTER lists 49 projects funded under PAR-21-321 in fiscal 2023 to 2026, at 49 institutions. The most were at Rutgers Biomedical and Health Sciences, University of Minnesota, University of Chicago.

Who has won Human Genome Research grants before?

The largest recipients over five fiscal years were The Leland Stanford Junior University, University of Washington, The Broad Institute, Inc. The program made 1,255 awards worth $2.2 billion in that time.

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