Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

PAR-21-138: Method to Extend Research in Time (MERIT) Award Extension Request (Type 4 Clinical Trial Optional)

Closed Closed December 1, 2024 Opportunity PAR-21-138

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.

National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on December 1, 2024.

From the official notice on Grants.gov, last changed June 4, 2021. Checked November 7, 2026.

About this NIH notice

The title gives no activity code; these are the codes of the projects NIH funded under it.

Projects funded under PAR-21-138 were run by National Cancer Institute (NCI, 167 projects) and National Institute of Dental and Craniofacial Research (NIDCR, 1 project). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read PAR-21-138 in the NIH Guide.

Key dates

PostedJune 3, 2021
DeadlineDecember 1, 2024
Archived by Grants.govJanuary 6, 2025

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

The National Cancer Institute (NCI) Method to Extend Research in Time (MERIT) (R37) Award provides extended grant support to Early Stage Investigators (ESIs). By providing such an opportunity for longer term support to ESIs, the NCI intends to offer flexibility and opportunity for creativity and innovation and additional time to successfully launch their careers and to become more established before having to submit renewal applications (NOT-CA-18-037). The objective of the NCI's ESI MERIT Award is to allow eligible investigators the opportunity to obtain up to 7 years of support in two segments:

Category: Education, Health.

Funded under PAR-21-138 so far

NIH funded 168 projects under PAR-21-138 in fiscal 2022 to 2026, at 82 institutions. The median yearly award was $450,318.

Most projects: Sloan-Kettering Inst Can Research (New York), 8, Fred Hutchinson Cancer Center (Washington), 7, University of Michigan at Ann Arbor (Michigan), 6, University of California, San Francisco (California), 6, Dana-Farber Cancer Inst (Massachusetts), 5.

Recently funded projects
ProjectInstitutionFiscal yearAward
Proteomic determinants of response to checkpoint blockade in malignant pleural mesothelioma R37University of California Los Angeles2026$407,412
Acupuncture for Chemotherapy-induced Peripheral Neuropathy Treatment (ACT) R37Dana-Farber Cancer Inst2026$659,998
Energy balance, mTOR pathway signaling, and breast cancer prognosis R37Ohio State University2026$766,371
Targeting Serine Auxotrophy in Luminal Breast Cancer R37University of Illinois at Chicago2026$359,689
Mechanisms of liver metastasis and associated resistance to immunotherapy R37Columbia University Health Sciences2026$342,055
Molecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene. R37Sloan-Kettering Inst Can Research2026$538,178
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer R37Fred Hutchinson Cancer Center2026$467,377
Advanced diffusion MRI for evaluating early response to radiation treatment in cervical cancer R37University of California, San Diego2026$648,284

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Cancer Treatment Research grants before

From fiscal 2021 to 2025, Cancer Treatment Research (93.395) awarded $5.6 billion across 3,622 grant awards, an average of $1.5 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Univeristy of Texas M.D. Anderson Cancer CenterTexas144$188 million
Dana-Farber Cancer Institute, Inc.Massachusetts68$185 million
Icahn School of Medicine at Mount SinaiNew York35$179 million
Public Health InstituteCalifornia4$168 million
Fred Hutchinson Cancer CenterWashington57$156 million

Top states: California ($843 million), New York ($604 million), Massachusetts ($568 million), Texas ($444 million), Pennsylvania ($417 million).

Who has won Cancer Biology Research grants before

From fiscal 2021 to 2025, Cancer Biology Research (93.396) awarded $4.3 billion across 3,142 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Trustees of Columbia University in the City of New YorkNew York70$151 million
The Univeristy of Texas M.D. Anderson Cancer CenterTexas109$144 million
Sloan-Kettering Institute for Cancer ResearchNew York66$136 million
Dana-Farber Cancer Institute, Inc.Massachusetts47$107 million
The Regents of the University of California, San FranciscoCalifornia64$95.5 million

Top states: New York ($712 million), California ($608 million), Massachusetts ($409 million), Texas ($373 million), Pennsylvania ($286 million).

Who has won Cancer Cause and Prevention Research grants before

From fiscal 2021 to 2025, Cancer Cause and Prevention Research (93.393) awarded $3.6 billion across 2,517 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Univeristy of Texas M.D. Anderson Cancer CenterTexas81$107 million
Sloan-Kettering Institute for Cancer ResearchNew York65$99.1 million
The Trustees of Columbia University in the City of New YorkNew York48$85.3 million
Dana-Farber Cancer Institute, Inc.Massachusetts51$83.1 million
University of North Carolina at Chapel HillNorth Carolina49$76.1 million

Top states: California ($465 million), New York ($445 million), Massachusetts ($350 million), Texas ($259 million), Pennsylvania ($175 million).

Other programs behind this notice

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is PAR-21-138 still open?

No. It closed on December 1, 2024.

Who can apply for Method to Extend Research in Time (MERIT) Award Extension Request (Type 4 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Method to Extend Research in Time (MERIT) Award Extension Request (Type 4 Clinical Trial Optional)?

Closed December 1, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has been funded under PAR-21-138?

NIH RePORTER lists 168 projects funded under PAR-21-138 in fiscal 2022 to 2026, at 82 institutions. The most were at Sloan-Kettering Inst Can Research, Fred Hutchinson Cancer Center, University of Michigan at Ann Arbor.

Who has won Cancer Cause and Prevention Research grants before?

The largest recipients over five fiscal years were The Univeristy of Texas M.D. Anderson Cancer Center, Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York. The program made 2,517 awards worth $3.6 billion in that time.

Similar open grants