PAR-21-083: NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)
Closed
This grant is closed. A newer notice from the same program is open now: NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required) (PAR-27-064). Status: Due dates in the notice, expires July 5, 2029. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants to small businesses. Applications closed on January 13, 2024.
From the official notice on Grants.gov, last changed January 14, 2021. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeCooperative Agreement
About this NIH notice
- Activity codeU01
- Clinical trialsRequired
- Funded byNIAID
- Median yearly award$1.0 million
- Typical project length5 years
- U01, Research Project Cooperative Agreement. Like an R01, but NIH staff are substantially involved in the work. Other open U01 notices.
Projects funded under PAR-21-083 were run by National Institute of Allergy and Infectious Diseases (NIAID, 25 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-21-083 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| PAR-27-064 | June 16, 2026 | Due dates in the notice, expires July 5, 2029 | Open |
| PAR-24-100 | January 29, 2024 | Closed May 23, 2025 | Closed |
Key dates
| Posted | January 14, 2021 |
|---|---|
| Deadline | January 13, 2024 |
| Archived by Grants.gov | February 18, 2024 |
Who can apply
This opportunity was open to small businesses.
- Small businesses
Is this a realistic fit?
- Most of the program's money (67% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This Funding Opportunity Announcement (FOA) encourages cooperative agreement applications for implementation of investigator-initiated, high-risk clinical trials and mechanistic studies associated with high-risk clinical trials. Mechanistic work in clinical trials may be of great value because it promotes the understanding of human diseases and the development of future therapeutic modalities. Investigators are encouraged to visit the NIAID website for additional information about the research mission and high-priority research areas of the NIAID (https://www.niaid.nih.gov/research/role). Only one clinical trial may be proposed in each NIAID Clinical Trial Implementation Cooperative Agreement (U01) application.
Funded under PAR-21-083 so far
NIH funded 25 projects under PAR-21-083 in fiscal 2022 to 2026, at 20 institutions. The median yearly award was $1.0 million.
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, PAR-27-064, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-21-083 still open?
No. It closed on January 13, 2024. A newer notice is open: PAR-27-064, due dates in the notice, expires July 5, 2029.
Who can apply for NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)?
National Institutes of Health accepted applications from small businesses.
What is the deadline for NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)?
Closed January 13, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under PAR-21-083?
NIH RePORTER lists 25 projects funded under PAR-21-083 in fiscal 2022 to 2026, at 20 institutions. The most were at Johns Hopkins University, University of California, San Francisco, Vanderbilt University Medical Center.
Who has won Allergy and Infectious Diseases Research grants before?
The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.
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