CDC-RFA-IP-25-0007: Strengthening Vaccine-Preventable Disease Prevention and Response
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of Centers for Disease Control - NCIRD notices from 2025.
Centers for Disease Control - NCIRD offered grants to state and local governments. It expected to make about 66 awards worth $2.0 billion in total. Applications closed on March 13, 2025.
From the official notice on Grants.gov, last changed January 6, 2025. Checked November 7, 2026.
- Total funding$2.0 billion
- Expected awards66
- Cost sharingNot required
- Funding typeCooperative Agreement
Key dates
| Posted | January 6, 2025 |
|---|---|
| Deadline | March 13, 2025 |
| Archived by Grants.gov | April 12, 2025 |
Who can apply
This opportunity was open to state and local governments.
- State governments
- County governments
- City or township governments
- Special district governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Applicants must meet certain population thresholds as described here. This strategy allows ISD to reach the greatest number of people while balancing the need for direct support to some of the largest cities in the United States. Eligible applicants include:• The 51 state health departments or their bona fide agents, including the District of Columbia. • Local health agencies or their bona fide agents, if they serve a city population* of 1.4 million or more (i.e., Chicago, Houston, New York City, Philadelphia, San Antonio). ◦ If the city does not have a public health department, then the county covering the jurisdiction may apply (i.e., Los Angeles, CA covered by Los Angeles County and Phoenix, AZ covered by Maricopa County). • All U.S. territories and the Freely Associated States in the Caribbean and Pacific (American Samoa, Commonwealth of the Northern Mariana Islands, Guam, Puerto Rico, the U.S. Virgin Islands, the Freely Associated States of the Federated States of Micronesia, Republic of Palau, and Republic of the Marshall Islands). Note: The Freely Associated States do not participate in the Vaccines for Children Program.*Population for city jurisdictions. Source: U.S. Census Bureau, 2022 American Community Survey 5-Year Data (2018 - 2022) - Table S0101.
Is this a realistic fit?
- Most of the program's money (100% over five years) went to state and local governments.
- No cost sharing or match is required.
What the grant funds
CDC’s Immunization Services Division (ISD) Notice of Funding Opportunity (NOFO) continues and builds upon the ongoing work of the Section 317 and Vaccines for Children (VFC) Programs. These programs remain central to the U.S. immunization program infrastructure to achieve high vaccination coverage, low incidence of vaccine-preventable disease (VPD) and maintain or improve response to vaccine-preventable public health threats. The VFC Program provides vaccines to children whose parents or guardians may not be able to afford them. Serving as an important contributor to health equity, the program helps support fair and just opportunities for all children to get their recommended vaccinations on schedule and achieve their highest level of health. Section 317 of the Public Health Service Act helps meet the costs of prevention health services, and 317 priorities include preserving immunization infrastructure, maintaining vaccine supply as a safety net for uninsured adults, and responding to VPD outbreaks. Activities in this funding opportunity are included within the following seven priority strategies. • Strengthen Program Infrastructure and Management. • Increase Vaccine Access. • Improve Vaccination Equity. • Promote Vaccine Confidence and Demand. • Enhance Data and Evaluation. There are three components in this NOFO, and you are required to apply to all three components. • Component 1: Core. • Component 2: Rapid small-scale response to VPD outbreaks or other public health emergencies (funded). • Component 3: Rapid large-scale response to VPD outbreaks or other public health emergencies (approved but unfunded).
Who has won Immunization Cooperative Agreements grants before
From fiscal 2021 to 2025, Immunization Cooperative Agreements (93.268) awarded $8.5 billion across 221 grant awards, an average of $38.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| California Department of Public Health | California | 2 | $935 million |
| Department of State Health Services | Texas | 2 | $594 million |
| Florida Department of Health | Florida | 3 | $476 million |
| NYS Department of Health | New York | 2 | $266 million |
| Pennsylvania Department of Health | Pennsylvania | 3 | $262 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is CDC-RFA-IP-25-0007 still open?
No. It closed on March 13, 2025.
Who can apply for Strengthening Vaccine-Preventable Disease Prevention and Response?
Centers for Disease Control - NCIRD accepted applications from state and local governments. The notice adds further conditions, so read its eligibility section.
What is the deadline for Strengthening Vaccine-Preventable Disease Prevention and Response?
Closed March 13, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
About $2.0 billion in total across about 66 awards.
Who has won Immunization Cooperative Agreements grants before?
The largest recipients over five fiscal years were California Department of Public Health, Department of State Health Services, Florida Department of Health. The program made 221 awards worth $8.5 billion in that time.
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