Grants for small businesses in Massachusetts
Federal agencies awarded $1.9 billion in 1,502 grants to small businesses in Massachusetts from fiscal 2021 to 2025. The largest source was Manufacturing and Energy Supply Chain Demonstrations and Commercial Applications. 769 federal grant opportunities are open or forecast now for small businesses.
- Massachusetts ranks 2nd of the 50 states and DC for federal grants to small businesses.
- Grants to small businesses made up 1% of all federal grant money to recipients in Massachusetts.
- That is 11% of all federal grant money to small businesses nationwide.
- Awarded, FY 2021 to 2025$1.9 billion
- Grant awards1,502
- Open now nationwide769
Federal programs that fund small businesses in Massachusetts
| Program | Awarded to small businesses in Massachusetts |
|---|---|
| Manufacturing and Energy Supply Chain Demonstrations and Commercial Applications | $396 million |
| Allergy and Infectious Diseases Research | $144 million |
| Office of Science Financial Assistance Program | $132 million |
| Aging Research | $132 million |
| Drug Use and Addiction Research Programs | $104 million |
| Technology, Innovation, and Partnerships | $94.1 million |
| Clean Energy Demonstrations | $86.9 million |
| Advanced Research Projects Agency - Energy | $86.3 million |
| Cancer Treatment Research | $58.7 million |
| Renewable Energy Research and Development | $57.4 million |
Open federal grants small businesses can apply for
- Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)
Open Closes November 2, 2026 (2 days left) - Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)
Open Closes November 2, 2026 (2 days left) - BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA)
Open Closes November 2, 2026 (2 days left) - OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support
Open Closes November 2, 2026 (2 days left) - Topology
Open Closes November 3, 2026 (3 days left) - Geometric Analysis
Open Closes November 3, 2026 (3 days left) - DoW Reconstructive Transplant, Concept Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Idea Development Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Resource Development Award
Open Closes November 4, 2026 (4 days left) - DoW Reconstructive Transplant, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - Exploring and Enhancing Outdoor and Heritage Tourism in the Chesapeake Bay Watershed
Open Closes November 4, 2026 (4 days left) - Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Open Closes November 5, 2026 (5 days left) - Request for Information - Gauging Investor Interest in the Development and Commercialization of Subsurface Energy Technologies
Open Closes November 5, 2026 (5 days left) - Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Early Investigator Research Award
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Investigator-Initiated Research Award
Open Closes November 6, 2026 (6 days left) - Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left) - Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Early-Stage Innovative Technology Development for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left) - Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left) - Pilot Projects to Enhance the Human Virome Program (R03 Clinical Trials Not Allowed)
Open Closes November 10, 2026 (10 days left) - DoW Vision, Clinical Trial Award
Open Closes November 12, 2026 (12 days left)
See all 769 open grants for small businesses