Grants for nonprofits in Missouri
Federal agencies awarded $2.2 billion in 1,622 grants to nonprofits in Missouri from fiscal 2021 to 2025. The largest source was Head Start. 856 federal grant opportunities are open or forecast now for nonprofits.
- Missouri ranks 24th of the 50 states and DC for federal grants to nonprofits.
- Grants to nonprofits made up 2% of all federal grant money to recipients in Missouri.
- That is 1% of all federal grant money to nonprofits nationwide.
- Awarded, FY 2021 to 2025$2.2 billion
- Grant awards1,622
- Open now nationwide856
Federal programs that fund nonprofits in Missouri
| Program | Awarded to nonprofits in Missouri |
|---|---|
| Head Start | $989 million |
| Refugee and Entrant Assistance State/Replacement Designee Administered Programs | $78.1 million |
| Substance Abuse and Mental Health Services Projects of Regional and National Significance | $71.9 million |
| VA Supportive Services for Veteran Families Program | $66.9 million |
| Regional Agricultural Promotion Program | $53.5 million |
| Science | $50.4 million |
| Office of Science Financial Assistance Program | $29.6 million |
| Charter Schools | $28.0 million |
| Special Programs for the Aging, Title IV, and Title II, Discretionary Projects | $25.6 million |
| Education Stabilization Fund | $23.2 million |
Nonprofits in Missouri that received the most
| Recipient | Awards | Amount |
|---|---|---|
| State of Missouri | 6 | $357 million |
Open federal grants nonprofits can apply for
- Small Business Transportation Technical Assistance Center (Region 1)
Open Closes today - Small Business Transportation Technical Assistance Center (Region 3)
Open Closes today - Region 4 Small Business Transportation Technical Assistance Center (SBTTAC)
Open Closes today - Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)
Open Closes November 2, 2026 (2 days left) - Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)
Open Closes November 2, 2026 (2 days left) - National Indian Health Outreach and Education
Open Closes November 2, 2026 (2 days left) - BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA)
Open Closes November 2, 2026 (2 days left) - BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program
Open Closes November 2, 2026 (2 days left) - OJJDP FY 2026 Second Chance Act Youth Reentry Program
Open Closes November 2, 2026 (2 days left) - OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support
Open Closes November 2, 2026 (2 days left) - Topology
Open Closes November 3, 2026 (3 days left) - Geometric Analysis
Open Closes November 3, 2026 (3 days left) - DoW Reconstructive Transplant, Concept Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Idea Development Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Resource Development Award
Open Closes November 4, 2026 (4 days left) - DoW Reconstructive Transplant, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - Exploring and Enhancing Outdoor and Heritage Tourism in the Chesapeake Bay Watershed
Open Closes November 4, 2026 (4 days left) - Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Open Closes November 5, 2026 (5 days left) - Emerging Infections Network - Research for Preventing, Detecting, and Managing Travel-associated Infectious Diseases
Open Closes November 5, 2026 (5 days left) - US Travelers Health Research, Surveillance, Communication, and Outreach Network
Open Closes November 5, 2026 (5 days left) - Request for Information - Gauging Investor Interest in the Development and Commercialization of Subsurface Energy Technologies
Open Closes November 5, 2026 (5 days left) - Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Early Investigator Research Award
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Investigator-Initiated Research Award
Open Closes November 6, 2026 (6 days left)
See all 856 open grants for nonprofits