Grants for businesses in Pennsylvania
Federal agencies awarded $1.1 billion in 217 grants to businesses in Pennsylvania from fiscal 2021 to 2025. The largest source was Clean Energy Demonstrations. 770 federal grant opportunities are open or forecast now for businesses.
- Pennsylvania ranks 13th of the 50 states and DC for federal grants to businesses.
- Grants to businesses made up 0% of all federal grant money to recipients in Pennsylvania.
- That is 1% of all federal grant money to businesses nationwide.
- Awarded, FY 2021 to 2025$1.1 billion
- Grant awards217
- Open now nationwide770
Federal programs that fund businesses in Pennsylvania
| Program | Awarded to businesses in Pennsylvania |
|---|---|
| Clean Energy Demonstrations | $221 million |
| Grid Infrastructure Deployment and Resilience | $169 million |
| Nuclear Energy Research, Development and Demonstration | $151 million |
| Defense Production Act Title III (DPA Title III) | $72.2 million |
| Consolidated Rail Infrastructure and Safety Improvements | $72.1 million |
| Manufacturing and Energy Supply Chain Demonstrations and Commercial Applications | $50.0 million |
| Education Stabilization Fund | $46.0 million |
| Partnerships for Climate-Smart Commodities | $40.0 million |
| Biomedical Advanced Research and Development Authority (BARDA), Biodefense Medical Countermeasure Development | $38.0 million |
| Research on Chemical and Biological Defense | $38.0 million |
Open federal grants businesses can apply for
- Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)
Open Closes November 2, 2026 (2 days left) - Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)
Open Closes November 2, 2026 (2 days left) - BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA)
Open Closes November 2, 2026 (2 days left) - OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support
Open Closes November 2, 2026 (2 days left) - Topology
Open Closes November 3, 2026 (3 days left) - Geometric Analysis
Open Closes November 3, 2026 (3 days left) - DoW Reconstructive Transplant, Concept Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Idea Development Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Resource Development Award
Open Closes November 4, 2026 (4 days left) - DoW Reconstructive Transplant, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - Exploring and Enhancing Outdoor and Heritage Tourism in the Chesapeake Bay Watershed
Open Closes November 4, 2026 (4 days left) - Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Open Closes November 5, 2026 (5 days left) - Emerging Infections Network - Research for Preventing, Detecting, and Managing Travel-associated Infectious Diseases
Open Closes November 5, 2026 (5 days left) - US Travelers Health Research, Surveillance, Communication, and Outreach Network
Open Closes November 5, 2026 (5 days left) - Request for Information - Gauging Investor Interest in the Development and Commercialization of Subsurface Energy Technologies
Open Closes November 5, 2026 (5 days left) - Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Early Investigator Research Award
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Investigator-Initiated Research Award
Open Closes November 6, 2026 (6 days left) - Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left) - Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Early-Stage Innovative Technology Development for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left) - Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left)
See all 770 open grants for businesses