| 1 | PA Department of Human Services · Harrisburg | State and local governments | 280 | $156 billion |
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| 2 | Pennsylvania Department of Transportation · Harrisburg | State and local governments | 6,997 | $14 billion |
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| 3 | Pennsylvania Dept of Education · Harrisburg | State and local governments | 144 | $12 billion |
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| 4 | Commonwealth of Pennsylvania Department of Education · Harrisburg | State and local governments | 30 | $7.5 billion |
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| 5 | The Trustees of the University of Pennsylvania · Philadelphia | Colleges and universities | 3,322 | $4.1 billion |
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| 6 | University of Pittsburgh - of the Commonwealth System of Higher Education · Pittsburgh | Colleges and universities | 3,064 | $3.9 billion |
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| 7 | Pennsylvania Department of Health · Harrisburg | State and local governments | 174 | $2.9 billion |
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| 8 | Southeastern Pennsylvania Transportation Authority · Philadelphia | State and local governments | 52 | $2.6 billion |
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| 9 | Department of Labor & Industry PA · Harrisburg | State and local governments | 134 | $2.6 billion |
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| 10 | Pennsylvania Emergency Management Agency · Harrisburg | State and local governments | 100 | $2.3 billion |
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| 11 | Department of Community & Economic Development Pennsylvania · Harrisburg | State and local governments | 89 | $2.3 billion |
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| 12 | Opportunity Finance Network · Philadelphia | Nonprofits | 5 | $2.3 billion |
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| 13 | Pennsylvania Department of Environmental Protection · Harrisburg | State and local governments | 122 | $2.2 billion |
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| 14 | The Pennsylvania State University · University Park | Colleges and universities | 2,271 | $1.8 billion |
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| 15 | Pennvest · Philadelphia | State and local governments | 33 | $1.6 billion |
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| 16 | Philadelphia Housing Authority · Philadelphia | State and local governments | 36 | $1.2 billion |
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| 17 | The Children's Hospital of Philadelphia · Philadelphia | Nonprofits | 651 | $1.0 billion |
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| 18 | Port Authority of Allegheny County Inc · Pittsburgh | State and local governments | 31 | $924 million |
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| 19 | Carnegie-Mellon University · Pittsburgh | Colleges and universities | 1,159 | $816 million |
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| 20 | Pennsylvania Department of Military & Veterans Affairs · Annville | State and local governments | 101 | $814 million |
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| 21 | Pennsylvania Department of Drug and Alcohol Programs · Harrisburg | State and local governments | 14 | $812 million |
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| 22 | Temple University-of the Commonwealth System of Higher Education · Philadelphia | Nonprofits | 713 | $664 million |
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| 23 | Pennsylvania Department of Insurance · Harrisburg | State and local governments | 2 | $646 million |
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| 24 | City of Philadelphia · Philadelphia | State and local governments | 26 | $568 million |
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| 25 | Drexel University · Philadelphia | Colleges and universities | 543 | $506 million |
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| 26 | PA Department of Aging · Harrisburg | State and local governments | 81 | $461 million |
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| 27 | Housing Authority of the City of Pittsburgh · Pittsburgh | State and local governments | 21 | $449 million |
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| 28 | City of Philadelphia P · Philadelphia | State and local governments | 32 | $439 million |
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| 29 | Pennsylvania State University · Hershey | Colleges and universities | 375 | $425 million |
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| 30 | Thomas Jefferson University · Philadelphia | Colleges and universities | 394 | $423 million |
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| 31 | County of Allegheny · Pittsburgh | State and local governments | 96 | $406 million |
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| 32 | National Center for Defense Manufacturing and Machining · Blairsville | Nonprofits | 4 | $313 million |
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| 33 | School District of Philadelphia · Philadelphia | State and local governments | 26 | $300 million |
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| 34 | Crime & Delinquency Pa Commission on · Harrisburg | State and local governments | 88 | $296 million |
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| 35 | Commonwealth of Pennsylvania · Harrisburg | State and local governments | 1 | $279 million |
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| 36 | City of Philadelphia · Philadelphia | State and local governments | 38 | $273 million |
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| 37 | Allegheny County Airport Authority · Pittsburgh | State and local governments | 41 | $210 million |
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| 38 | The Wistar Institute of Anatomy and Biology · Philadelphia | Nonprofits | 105 | $206 million |
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| 39 | Lehigh University · Bethlehem | Colleges and universities | 322 | $194 million |
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| 40 | The Reinvestment Fund, Inc. · Philadelphia | Nonprofits | 18 | $190 million |
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| 41 | Ecog-Acrin Medical Research Foundation, Inc. · Philadelphia | Nonprofits | 11 | $188 million |
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| 42 | Department of Agriculture Pennsylvania · Harrisburg | State and local governments | 208 | $176 million |
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| 43 | Phila Department Public Health · Philadelphia | State and local governments | 13 | $176 million |
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| 44 | Kraft Heinz Foods Company · Pittsburgh | Businesses | 1 | $171 million |
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| 45 | Game Commission, Pennsylvania · Harrisburg | State and local governments | 46 | $165 million |
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| 46 | Energy Development Authority · Harrisburg | State and local governments | 1 | $156 million |
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| 47 | Philadelphia Regional Port Authority · Philadelphia | State and local governments | 7 | $153 million |
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| 48 | Executive Office of the Commonwealth of Pennsylvania · Harrisburg | State and local governments | 1 | $153 million |
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| 49 | NRG Oncology Foundation Inc · Philadelphia | Nonprofits | 5 | $151 million |
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| 50 | Magee-Womens Research Institute and Foundation · Pittsburgh | Nonprofits | 78 | $151 million |
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| 51 | Westinghouse Electric Company LLC · Cranberry Township | Businesses | 6 | $141 million |
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| 52 | The Institute for Cancer Research · Philadelphia | Nonprofits | 125 | $134 million |
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| 53 | City of Philadelphia · Philadelphia | State and local governments | 3 | $125 million |
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| 54 | The Wright Center for Graduate Medical Education · Scranton | Other | 26 | $120 million |
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| 55 | Department of Conservation & Natural Resources Pennsylvania · Harrisburg | State and local governments | 122 | $120 million |
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| 56 | Allegheny County Housing · Mc Kees Rocks | State and local governments | 285 | $115 million |
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| 57 | Community College of Philadelphia · Philadelphia | State and local governments | 14 | $110 million |
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| 58 | Council of 3 Rivers American Indian Center · Pittsburgh | Nonprofits | 13 | $100 million |
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| 59 | Peco Energy Company · Philadelphia | Businesses | 1 | $100 million |
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| 60 | Pennsylvania Association for Sustainable Agriculture · Harrisburg | Nonprofits | 6 | $97.4 million |
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| 61 | Veterans Multi-Service Center Inc · Philadelphia | Nonprofits | 37 | $96.2 million |
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| 62 | Department of State Police Pennsylvania · Harrisburg | State and local governments | 22 | $96.1 million |
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| 63 | Ompi of America Inc · Newtown | Businesses | 2 | $94.5 million |
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| 64 | Susquehanna Area Regional Airport Authority · Middletown | State and local governments | 46 | $92.6 million |
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| 65 | Holy Family Institute · Pittsburgh | Nonprofits | 10 | $89.6 million |
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| 66 | City of Pittsburgh · Pittsburgh | State and local governments | 24 | $88.7 million |
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| 67 | Harrisburg Housing Authority · Harrisburg | State and local governments | 67 | $85.7 million |
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| 68 | Mercyhurst University · Erie | Colleges and universities | 28 | $85.0 million |
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| 69 | Public Health Management Corp · Philadelphia | Nonprofits | 33 | $85.0 million |
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| 70 | Lehigh Northampton Airport Authority · Allentown | State and local governments | 19 | $84.1 million |
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| 71 | Private Industry Council of Westmoreland/ Fayette, Inc. · Greensburg | Nonprofits | 7 | $83.5 million |
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| 72 | Lehigh & Northampton Transportation Authority · Allentown | State and local governments | 19 | $80.8 million |
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| 73 | Susquehanna Regional Transportation Authority · Harrisburg | State and local governments | 20 | $79.8 million |
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| 74 | Attorney General Pa Office of · Harrisburg | State and local governments | 13 | $73.7 million |
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| 75 | Beaver County Housing Authorty · Beaver | State and local governments | 80 | $73.3 million |
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| 76 | Housing Authority of the City of Erie (Inc) · Erie | State and local governments | 49 | $72.7 million |
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| 77 | Fish & Boat Commission, Pennsylvania · Harrisburg | State and local governments | 65 | $72.4 million |
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| 78 | Child Development Centers, Inc. · Erie | Nonprofits | 5 | $71.1 million |
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| 79 | Kidspeace Corporation · Schnecksville | Nonprofits | 4 | $71.1 million |
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| 80 | Board of Public Education School District of Pittsburgh · Pittsburgh | State and local governments | 9 | $69.6 million |
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| 81 | Constellation Energy Generation, LLC · Kennett Square | Businesses | 3 | $69.5 million |
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| 82 | Geisinger Clinic · Danville | Nonprofits | 50 | $68.9 million |
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| 83 | Reading Housing Authority · Reading | State and local governments | 38 | $67.2 million |
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| 84 | Kutztown University of Pennsylvania · Kutztown | Colleges and universities | 26 | $67.0 million |
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| 85 | West Chester University of Pennsylvania · West Chester | Colleges and universities | 32 | $66.4 million |
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| 86 | Community Services for Children Inc · Allentown | Nonprofits | 4 | $64.1 million |
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| 87 | Upmc Children's Hospital of Pittsburgh · Pittsburgh | Other | 1 | $63.9 million |
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| 88 | Primary Health Network · Sharon | Nonprofits | 9 | $63.3 million |
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| 89 | Lincoln University · Lincoln University | Colleges and universities | 21 | $63.0 million |
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| 90 | Indiana University of Pennsylvania · Indiana | Colleges and universities | 21 | $62.6 million |
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| 91 | Westmoreland County Housing Authority · Greensburg | Tribal governments and organizations | 106 | $62.5 million |
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| 92 | The Harrisburg Area Community College Foundation · Harrisburg | State and local governments | 5 | $62.3 million |
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| 93 | Johnstown Housing Authority · Johnstown | State and local governments | 61 | $61.0 million |
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| 94 | Scranton Housing Authority · Scranton | State and local governments | 41 | $60.8 million |
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| 95 | Pennsylvania Coalition Against Domestic Violence · Harrisburg | Nonprofits | 45 | $60.2 million |
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| 96 | Agency for Community Empowerment of Nepa · Scranton | Nonprofits | 5 | $59.2 million |
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| 97 | Consolidated Rail Corporation · Harrisburg | Businesses | 1 | $59.1 million |
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| 98 | Greater Philadelphia Health Action Inc · Philadelphia | Other | 9 | $58.7 million |
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| 99 | South Central Transit Authority · Lancaster | State and local governments | 23 | $57.8 million |
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| 100 | Villanova University in the State of Pennsylvania · Villanova | Colleges and universities | 135 | $56.9 million |
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