Federal grant programs / Department of Health and Human Services

21st Century Cures Act - Beau Biden Cancer Moonshot (93.353)

Also known as moonshot

• Awarded, FY 2021 to 2025$494 million
• Grant awards244
• Typical award$1.5 million
• Awarded in FY 2025$108 million
• Size rank377 of 1,823
• Type of assistanceProject grants

Key findings

• Annual funding fell from $114 million in fiscal 2021 to $108 million in fiscal 2025.
• It is the 377th largest of 1,823 federal grant programs by five-year awards.
• The 20 largest recipients received 65% of the money.
• Awards went to recipients in 35 states and territories.

What the program funds

To provide support for initiatives funded under the 21st Century Cures Act to support cancer research, such as the development of cancer vaccines, the development of more sensitive diagnostic tests for cancer, immunotherapy and the development of combination therapies, and research that has the potential to transform the scientific field, that has inherently higher risk, and that seeks to address major challenges related to cancer.

From the federal Assistance Listing. Read the full listing on SAM.gov.

Open opportunities

• Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
  Open · Due dates in the notice, expires July 12, 2027
• Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
  Open · Due dates in the notice, expires July 17, 2027

Rules from the program listing

Who can apply

The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that applies and receives a grant for support of research by a named principal investigator. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

What the money can and cannot pay for

Grants and cooperative agreements may be made to eligible institutions for the support of cancer research projects. The grants and cooperative agreements may be used for personnel, consultant costs, equipment, supplies, travel, patient costs, animals, alterations and renovations, miscellaneous items, and Facilities and Administrative Costs (formerly known as indirect costs).

Matching requirements

This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.

Award range and average, in the agency's words

Range: $226,154 to $3,109,346 Average $1,162,016

Quoted from the program's federal Assistance Listing. The notice of funding opportunity is the official source for each competition's rules.

Who usually wins

Colleges and universities received 65% of the money, nonprofits 34% and small businesses 0.6%.

By state

31 states have a page for this program: those that received at least $1 million or 10 awards.

Award amounts are federal obligations reported to USAspending.gov for fiscal 2021 to 2025; see how our data works.