RFA-TR-22-030: Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)
Closed
This grant is closed. A newer notice from the same program is open now: Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) (PAR-25-122). Status: Due dates in the notice, expires November 16, 2027. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants of up to $100,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on July 15, 2024.
From the official notice on Grants.gov, last changed June 28, 2022. Checked November 7, 2026.
- Award ceiling$100,000
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR03
- Clinical trialsNot allowed
- Funded byNCATS, NINDS, NIMH
- Median yearly award$157,750
- Typical project length1 year
- R03, Small Grant. A small, short project such as pilot work, a feasibility study, secondary data analysis or a new method, usually for up to two years. Other open R03 notices.
Projects funded under RFA-TR-22-030 were run by National Center for Advancing Translational Sciences (NCATS, 44 projects), National Institute of Neurological Disorders and Stroke (NINDS, 8 projects), National Institute of Mental Health (NIMH, 5 projects) and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, 1 project). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-TR-22-030 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| PAR-25-122 | October 28, 2024 | Due dates in the notice, expires November 16, 2027 | Open |
Key dates
| Posted | June 28, 2022 |
|---|---|
| Deadline | July 15, 2024 |
| Archived by Grants.gov | August 20, 2024 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $157,750; it allows up to $100,000 per award.
- Most of the money in the 2 programs behind this notice (73% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this funding opportunity announcement (FOA) is to solicit applications for pilot projects to elucidate a role for understudied proteins associated with rare diseases. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s).
Funded under RFA-TR-22-030 so far
NIH funded 58 projects under RFA-TR-22-030 in fiscal 2023 to 2025, at 47 institutions. The median yearly award was $157,750.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Screening Variants of Unknown Significance to Identify Pathogenic Variants of the Manganese Transporter SLC39A8 | Michigan State University | 2025 | $148,248 |
| Development of Bone Marrow Organoid System to Study RUNX1-Familial Platelet Disorder with Associated Myeloid Malignancy (RUNX1-FPD/MM) | Boston Children's Hospital | 2025 | $178,000 |
| Localization and function of SLC24A5 in skin pigmentation | Children's Hosp of Philadelphia | 2025 | $178,000 |
| A mouse model of HUWE1 syndrome | Kent State University | 2025 | $151,809 |
| Impact of a Histone H3K9 Methyltransferase on Mitochondria | University of Delaware | 2025 | $155,559 |
| Mechanisms for control of mitoribosome assembly by the GTPase ERAL1 | Brandeis University | 2025 | $157,260 |
| High-Content Analysis to Accelerate Mechanistic and Therapeutic Identification for ABCA3 Deficiency | Washington University | 2025 | $155,500 |
| The ubiquitin ligase Itch limits mTORC1 nutrient sensing in B cells | University of Florida | 2025 | $152,500 |
Who has won Mental Health Research Grants grants before
From fiscal 2021 to 2025, Mental Health Research Grants (93.242) awarded $8.8 billion across 6,785 grant awards, an average of $1.3 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 185 | $371 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 200 | $297 million |
| University of California, Los Angeles | California | 176 | $234 million |
| Icahn School of Medicine at Mount Sinai | New York | 144 | $212 million |
| The Washington University | Missouri | 149 | $211 million |
Who has won National Center for Advancing Translational Sciences grants before
From fiscal 2021 to 2025, National Center for Advancing Translational Sciences (93.350) awarded $3.1 billion across 867 grant awards, an average of $3.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 15 | $95.3 million |
| Vanderbilt University Medical Center | Tennessee | 10 | $94.6 million |
| Duke University | North Carolina | 11 | $88.9 million |
| University of North Carolina at Chapel Hill | North Carolina | 16 | $74.5 million |
| The Johns Hopkins University | Maryland | 20 | $70.7 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, PAR-25-122, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-TR-22-030 still open?
No. It closed on July 15, 2024. A newer notice is open: PAR-25-122, due dates in the notice, expires November 16, 2027.
Who can apply for Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)?
Closed July 15, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $100,000 each.
Who has been funded under RFA-TR-22-030?
NIH RePORTER lists 58 projects funded under RFA-TR-22-030 in fiscal 2023 to 2025, at 47 institutions. The most were at Children's Hosp of Philadelphia, Washington University, Boston Children's Hospital.
Who has won Mental Health Research Grants grants before?
The largest recipients over five fiscal years were Yale Univ, University of Pittsburgh - of the Commonwealth System of Higher Education, University of California, Los Angeles. The program made 6,785 awards worth $8.8 billion in that time.
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