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Grants / Department of Health and Human Services / National Institutes of Health

RFA-RM-24-005: NIH Directors Early Independence Awards (DP5 Clinical Trial Optional)

Closed Closed September 6, 2024 Opportunity RFA-RM-24-005

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.

National Institutes of Health offered grants of up to $250,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on September 6, 2024.

From the official notice on Grants.gov, last changed March 19, 2024. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-RM-24-005 were run by NIH Office of the Director (OD, 16 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-RM-24-005 in the NIH Guide.

Other notices with this title

National Institutes of Health has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
RFA-RM-23-007March 28, 2023Closed September 6, 2023Closed
RFA-RM-22-021April 27, 2022Closed September 2, 2022Closed
RFA-RM-21-018April 26, 2021Closed September 3, 2021Closed

Key dates

PostedMarch 19, 2024
DeadlineSeptember 6, 2024
Archived by Grants.govOctober 12, 2024

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

The NIH Director's Early Independence Award supports rigorous and promising junior investigators who wish to pursue independent research soon after completion of their terminal doctoral degree or post-graduate clinical training, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the research workforce. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIHs Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply to this Notice of Funding Opportunity. In addition, applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Director's Early Independence Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.

Category: Health.

Funded under RFA-RM-24-005 so far

NIH funded 16 projects under RFA-RM-24-005 in fiscal 2025 to 2026, at 11 institutions. The median yearly award was $406,250.

Most projects: Washington University (Missouri), 2, University of California, San Francisco (California), 2, Massachusetts General Hospital (Massachusetts), 2, Stanford University (California), 2, University of Pennsylvania (Pennsylvania), 2.

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Trans-NIH Research Support grants before

From fiscal 2021 to 2025, Trans-NIH Research Support (93.310) awarded $5.9 billion across 4,433 grant awards, an average of $1.3 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Duke UniversityNorth Carolina66$219 million
The Leland Stanford Junior UniversityCalifornia104$176 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania82$154 million
The Johns Hopkins UniversityMaryland95$152 million
Yale UnivConnecticut85$149 million

Top states: California ($992 million), Massachusetts ($571 million), New York ($548 million), Pennsylvania ($445 million), North Carolina ($387 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-RM-24-005 still open?

No. It closed on September 6, 2024.

Who can apply for NIH Directors Early Independence Awards (DP5 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for NIH Directors Early Independence Awards (DP5 Clinical Trial Optional)?

Closed September 6, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $250,000 each.

Who has been funded under RFA-RM-24-005?

NIH RePORTER lists 16 projects funded under RFA-RM-24-005 in fiscal 2025 to 2026, at 11 institutions. The most were at Washington University, University of California, San Francisco, Massachusetts General Hospital.

Who has won Trans-NIH Research Support grants before?

The largest recipients over five fiscal years were Duke University, The Leland Stanford Junior University, University of Pittsburgh - of the Commonwealth System of Higher Education. The program made 4,433 awards worth $5.9 billion in that time.

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