RFA-OD-25-008: Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2025.
National Institutes of Health offered grants of up to $75,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on July 14, 2026.
From the official notice on Grants.gov, last changed June 24, 2025. Checked November 7, 2026.
- Award ceiling$75,000
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR03
- Clinical trialsOptional
- Funded byNIDA, NHLBI
- Median yearly award$123,562
- Typical project length2 years
- R03, Small Grant. A small, short project such as pilot work, a feasibility study, secondary data analysis or a new method, usually for up to two years. Other open R03 notices.
Projects funded under RFA-OD-25-008 were run by National Institute on Drug Abuse (NIDA, 2 projects) and National Heart Lung and Blood Institute (NHLBI, 2 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-OD-25-008 in the NIH Guide.
Key dates
| Posted | June 24, 2025 |
|---|---|
| Deadline | July 14, 2026 |
| Archived by Grants.gov | August 19, 2026 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $123,562; it allows up to $75,000 per award.
- Most of the program's money (77% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This Notice of Funding Opportunity (NOFO) aims to support new biomedical, behavioral, and social science investigators who are in the early stages of establishing independent careers in tobacco regulatory research. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects, development of research methodology, and development of new research technology. Applicants are encouraged to conduct projects that ultimately have the potential to inform regulations on tobacco product manufacturing, distribution, and marketing. Research projects must address one or more High-Priority Research Topic(s) related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this NOFO will be administered by NIH using funds made available through FDA CTP and the FSPTCA. Research results from this NOFO are expected to generate findings and data directly relevant to informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.
Funded under RFA-OD-25-008 so far
NIH funded 4 projects under RFA-OD-25-008 in fiscal 2026, at 3 institutions. The median yearly award was $123,562.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Using a physiologically relevant model to identify the effect of filler materials on nicotine delivery from oral nicotine pouches | Roswell Park Cancer Institute Corp | 2026 | $130,125 |
| Associations between ENDS characteristics and experimentation and initiation of cigarettes and ENDS in youth and young adults | University of Michigan at Ann Arbor | 2026 | $117,000 |
| Comparative Cardiovascular Effects of Combustible and Electronic Cigarettes in Older Adults with Hypertension | University of Maryland Baltimore | 2026 | $116,625 |
| Electronic Nicotine Delivery Systems (ENDS) Use Duration and Cardiopulmonary Outcomes: Evidence to Inform FDA Regulation | University of Michigan at Ann Arbor | 2026 | $234,000 |
Who has won Family Smoking Prevention and Tobacco Control Act Regulatory Research grants before
From fiscal 2021 to 2025, Family Smoking Prevention and Tobacco Control Act Regulatory Research (93.077) awarded $313 million across 176 grant awards, an average of $1.8 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 10 | $28.4 million |
| University of Southern California | California | 6 | $23.0 million |
| University of North Carolina at Chapel Hill | North Carolina | 11 | $20.9 million |
| Regents of the University of Michigan | Michigan | 3 | $20.3 million |
| The Ohio State University | Ohio | 9 | $18.9 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-OD-25-008 still open?
No. It closed on July 14, 2026.
Who can apply for Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional)?
Closed July 14, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $75,000 each.
Who has been funded under RFA-OD-25-008?
NIH RePORTER lists 4 projects funded under RFA-OD-25-008 in fiscal 2026, at 3 institutions. The most were at University of Michigan at Ann Arbor, Roswell Park Cancer Institute Corp, University of Maryland Baltimore.
Who has won Family Smoking Prevention and Tobacco Control Act Regulatory Research grants before?
The largest recipients over five fiscal years were Yale Univ, University of Southern California, University of North Carolina at Chapel Hill. The program made 176 awards worth $313 million in that time.
Similar open grants
- Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Pilot Projects to Enhance the Human Virome Program (R03 Clinical Trials Not Allowed)
- Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)
- Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)
- NICHD Small Research Grant Program (R03 Clinical Trial Required)