RFA-OD-25-001: High-Priority Research in Tobacco Regulatory Science (R01 Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on June 6, 2025.
From the official notice on Grants.gov, last changed December 5, 2024. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR01
- Clinical trialsOptional
- Funded byNHLBI, NIDA
- Median yearly award$782,293
- Typical project length5 years
- R01, Research Project Grant. NIH's standard grant for a defined research project led by a named investigator, usually for up to five years. Other open R01 notices.
Projects funded under RFA-OD-25-001 were run by National Heart Lung and Blood Institute (NHLBI, 3 projects) and National Institute on Drug Abuse (NIDA, 2 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-OD-25-001 in the NIH Guide.
Key dates
| Posted | December 5, 2024 |
|---|---|
| Deadline | June 6, 2025 |
| Archived by Grants.gov | July 12, 2025 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the program's money (77% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this Notice of Funding Opportunity (NOFO) is to invite R01 applications to support new high-priority biomedical and behavioral research that will provide scientific data to inform the regulation of tobacco products to protect public health. Research Projects must address the current high-priority research topics related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The awards under this NOFO will be administered by NIH using funds that have been made available through FDA CTP and the Family Smoking Prevention and Tobacco Control Act (P.L. 111-31). Research results from this NOFO are expected to generate findings and data that are directly relevant in informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.
Funded under RFA-OD-25-001 so far
NIH funded 5 projects under RFA-OD-25-001 in fiscal 2026, at 4 institutions. The median yearly award was $782,293.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Cardiorespiratory and autonomic impacts of coolants in e-cigarette aerosols | University of Louisville | 2026 | $782,293 |
| Research to Inform Comprehensive Regulation of Oral Nicotine Pouches | Ohio State University | 2026 | $773,576 |
| Assessing whether use of fruit flavored ENDS relates to smoking reductions in people who smoke cigarettes: A data triangulation approach to maximize internal and external validity | Roswell Park Cancer Institute Corp | 2026 | $867,448 |
| Assessing the Respiratory Effects of Inhaling Synthetic Coolants Used as Flavor Ingredients in ENDS | Roswell Park Cancer Institute Corp | 2026 | $830,722 |
| Advancing tobacco regulatory science with a holistic approach to connect ENDS characteristics and toxicological hazard analysis | Research Triangle Institute | 2026 | $616,521 |
Who has won Family Smoking Prevention and Tobacco Control Act Regulatory Research grants before
From fiscal 2021 to 2025, Family Smoking Prevention and Tobacco Control Act Regulatory Research (93.077) awarded $313 million across 176 grant awards, an average of $1.8 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 10 | $28.4 million |
| University of Southern California | California | 6 | $23.0 million |
| University of North Carolina at Chapel Hill | North Carolina | 11 | $20.9 million |
| Regents of the University of Michigan | Michigan | 3 | $20.3 million |
| The Ohio State University | Ohio | 9 | $18.9 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-OD-25-001 still open?
No. It closed on June 6, 2025.
Who can apply for High-Priority Research in Tobacco Regulatory Science (R01 Clinical Trial Optional)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for High-Priority Research in Tobacco Regulatory Science (R01 Clinical Trial Optional)?
Closed June 6, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-OD-25-001?
NIH RePORTER lists 5 projects funded under RFA-OD-25-001 in fiscal 2026, at 4 institutions. The most were at Roswell Park Cancer Institute Corp, University of Louisville, Ohio State University.
Who has won Family Smoking Prevention and Tobacco Control Act Regulatory Research grants before?
The largest recipients over five fiscal years were Yale Univ, University of Southern California, University of North Carolina at Chapel Hill. The program made 176 awards worth $313 million in that time.
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