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Grants / Department of Health and Human Services / National Institutes of Health

RFA-MH-21-230: Pilot Effectiveness Trials of Interventions for Preschoolers with ADHD (R34 Clinical Trial Required)

Closed Closed March 1, 2022 Opportunity RFA-MH-21-230

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.

National Institutes of Health offered grants of up to $225,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make about 5 awards worth $1.3 million in total. Applications closed on March 1, 2022.

From the official notice on Grants.gov, last changed April 19, 2021. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-MH-21-230 were run by National Institute of Mental Health (NIMH, 2 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-MH-21-230 in the NIH Guide.

Key dates

PostedApril 19, 2021
DeadlineMarch 1, 2022
Archived by Grants.govApril 6, 2022

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

ADHD is a neurodevelopmental disorder with symptoms and impairments that emerge early and persist into adulthood for a substantial portion of affected individuals. While evidence-based treatments exist for school-age children and adolescents with ADHD, findings from longitudinal research suggests that children and adolescents who receive evidence-based interventions for ADHD remain significantly impaired relative to their non-ADHD peers over time. Early identification and intervention for young children with ADHD may be a necessary first step in normalizing symptoms across development and mitigating negative outcomes. The number of preschool children diagnosed with ADHD has been growing in recent years, more than doubling between 2007 and 2016 (Danielson et al., 2017). This increase may be due in part to the 2011 expansion of the American Academy of Pediatrics (AAP) ADHD Clinical Practice Guideline to include recommendations for children as young as 4-years-old (Wolraich et al., 2019). Behavioral interventions are recommended in the AAP Guideline as the first-line treatment for preschoolers with ADHD symptoms, due largely to parental preferences and data suggesting a higher rate of ADHD medication-related side effects and adverse events among younger children. Yet little research has been conducted to test the effectiveness of behavioral interventions in this population. A handful of completed NIMH-funded efficacy studies support the feasibility and promise of conducting interventions research in the preschool ADHD population. However, no preschool ADHD effectiveness trials designed to test service-ready, scalable approaches have been funded by NIMH to date, further highlighting the need for research in this area.

Category: Health.

Funded under RFA-MH-21-230 so far

NIH funded 2 projects under RFA-MH-21-230 in fiscal 2023 to 2025, at 2 institutions. The median yearly award was $238,500.

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Mental Health Research Grants grants before

From fiscal 2021 to 2025, Mental Health Research Grants (93.242) awarded $8.8 billion across 6,785 grant awards, an average of $1.3 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Yale UnivConnecticut185$371 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania200$297 million
University of California, Los AngelesCalifornia176$234 million
Icahn School of Medicine at Mount SinaiNew York144$212 million
The Washington UniversityMissouri149$211 million

Top states: California ($1.4 billion), Massachusetts ($1.1 billion), New York ($1.1 billion), Pennsylvania ($667 million), Connecticut ($422 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-MH-21-230 still open?

No. It closed on March 1, 2022.

Who can apply for Pilot Effectiveness Trials of Interventions for Preschoolers with ADHD (R34 Clinical Trial Required)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Pilot Effectiveness Trials of Interventions for Preschoolers with ADHD (R34 Clinical Trial Required)?

Closed March 1, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $225,000 each. About $1.3 million in total across about 5 awards.

Who has been funded under RFA-MH-21-230?

NIH RePORTER lists 2 projects funded under RFA-MH-21-230 in fiscal 2023 to 2025, at 2 institutions. The most were at University of Pittsburgh at Pittsburgh, Duke University.

Who has won Mental Health Research Grants grants before?

The largest recipients over five fiscal years were Yale Univ, University of Pittsburgh - of the Commonwealth System of Higher Education, University of California, Los Angeles. The program made 6,785 awards worth $8.8 billion in that time.

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