RFA-DA-23-003: Investigating Transposable Elements and Mobile DNA as Targets of Integration for Establishing HIV Reservoirs in the Brain (R61/R33 - Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on August 3, 2022.
From the official notice on Grants.gov, last changed February 11, 2022. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR61 / R33
- Clinical trialsOptional
- Funded byNIDA
- Median yearly award$722,475
- Typical project length4 years
- R61, Exploratory/Developmental Phase I. The first phase of a phased award. Moving on to the R33 phase depends on meeting agreed milestones. Other open R61 notices.
- R33, Exploratory/Developmental Grant Phase II. The second phase of a phased award, usually following an R61 or R21 phase. Other open R33 notices.
Projects funded under RFA-DA-23-003 were run by National Institute on Drug Abuse (NIDA, 2 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-DA-23-003 in the NIH Guide.
Key dates
| Posted | February 11, 2022 |
|---|---|
| Deadline | August 3, 2022 |
| Archived by Grants.gov | September 8, 2022 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the program's money (70% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
oMany substances of abuse, including cocaine, methamphetamine, and several opioids exert powerful environmental insults on genomic DNA in the brain that induce expression of transposable elements and other mobile DNA. Transposable elements and mobile DNA, which comprise almost 50% of the human genome, are typically silenced through strong epigenetic modifications. When transposable elements and mobile DNA become active in people who use drugs of abuse, they potentially provide multiple integration sites for HIV in microglia. HIV integration into these unstable regions could lead to major chromosomal rearrangements and global dysregulation of transcription, ultimately contributing to HIV-associated Neurocognitive Disorder (HAND) and providing a mechanism by which drugs of abuse increase the probability of reactivating microglial HIV reservoirs. Understanding the factors that influence HIV integration in these microglial reservoirs is crucial to developing next-generation HIV therapies and potential cures. This concept addresses these gaps by fostering studies aimed at providing a deeper understanding of the complex interplay among HIV, substances of abuse, inflammation, and disease progression.
Funded under RFA-DA-23-003 so far
NIH funded 2 projects under RFA-DA-23-003 in fiscal 2023 to 2026, at 1 institution. The median yearly award was $722,475.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| HERV proteogenomics of narcotic-driven HIV latency | Icahn School of Medicine at Mount Sinai | 2026 | $722,475 |
| HERV proteogenomics of narcotic-driven HIV latency | Icahn School of Medicine at Mount Sinai | 2025 | $722,475 |
Who has won Drug Use and Addiction Research Programs grants before
From fiscal 2021 to 2025, Drug Use and Addiction Research Programs (93.279) awarded $7.3 billion across 5,071 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 150 | $305 million |
| The Johns Hopkins University | Maryland | 156 | $262 million |
| University of California, San Diego | California | 120 | $242 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 100 | $182 million |
| New York University | New York | 62 | $173 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-DA-23-003 still open?
No. It closed on August 3, 2022.
Who can apply for Investigating Transposable Elements and Mobile DNA as Targets of Integration for Establishing HIV Reservoirs in the Brain (R61/R33 - Clinical Trial Optional)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Investigating Transposable Elements and Mobile DNA as Targets of Integration for Establishing HIV Reservoirs in the Brain (R61/R33 - Clinical Trial Optional)?
Closed August 3, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-DA-23-003?
NIH RePORTER lists 2 projects funded under RFA-DA-23-003 in fiscal 2023 to 2026, at 1 institution.
Who has won Drug Use and Addiction Research Programs grants before?
The largest recipients over five fiscal years were Yale Univ, The Johns Hopkins University, University of California, San Diego. The program made 5,071 awards worth $7.3 billion in that time.
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