RFA-AI-22-069: Cooperative Centers on Human Immunology (U19 Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants of up to $2.5 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on April 7, 2023.
From the official notice on Grants.gov, last changed November 15, 2022. Checked November 7, 2026.
- Award ceiling$2.5 million
- Cost sharingNot required
- Funding typeCooperative Agreement
About this NIH notice
- Activity codeU19
- Clinical trialsOptional
- Funded byNIAID
- Median yearly award$413,646
- Typical project length10 years
- U19, Research Program Cooperative Agreement. Several related projects under one award, with substantial NIH involvement. Other open U19 notices.
Projects funded under RFA-AI-22-069 were run by National Institute of Allergy and Infectious Diseases (NIAID, 9 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AI-22-069 in the NIH Guide.
Key dates
| Posted | November 14, 2022 |
|---|---|
| Deadline | April 7, 2023 |
| Archived by Grants.gov | May 13, 2023 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $413,646; it allows up to $2.5 million per award.
- Most of the program's money (67% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This Funding Opportunity Announcement (FOA) seeks to solicit applications from interdisciplinary teams to participate in the Cooperative Centers on Human Immunology (CCHI) program. The program supports mechanistic and hypothesis-testing studies to discover novel molecules, mechanisms, or regulatory pathways governing function of the human immune system in both healthy and vulnerable populations (i.e., across lifespan, organ/tissue transplant recipients, pregnant women). Studies of interest include immunity related to prevention or treatment of infectious diseases, immune-mediated pathogenesis/sequelae associated with infectious disease, and/or immune-mediated diseases. This FOA also supports technology development to advance studies of the human immune system. The overarching goal of the CCHI is to provide foundational information on human immune system function to support translation of immunology research into clinical benefits.
Funded under RFA-AI-22-069 so far
NIH funded 9 projects under RFA-AI-22-069 in fiscal 2024 to 2026, at 9 institutions. The median yearly award was $413,646.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Administrative Core | La Jolla Institute for Immunology | 2026 | $514,689 |
| Clinical Phenotyping and Molecular Integration Core | Northwestern University | 2026 | $659,967 |
| Administrative Core | Jackson Laboratory | 2026 | $155,358 |
| Evolution and Durability of Human T and B Cell Responses | University of Alabama at Birmingham | 2026 | $3.5 million |
| Identifying and understanding the mechanisms for increased risk of severe infection in obesity and diabetes | Stanford University | 2026 | $314,399 |
| Immune Mechanisms Regulating the Development of Systemic and Mucosal Antigen-specific B Cells After Vaccination and Challenge in Humans | University of Maryland Baltimore | 2026 | $432,578 |
| Project 1 | Washington University | 2026 | $476,069 |
| Durable Alteration of the Human Immune system after Infection or Immunotherapy | Massachusetts General Hospital | 2026 | $2.3 million |
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AI-22-069 still open?
No. It closed on April 7, 2023.
Who can apply for Cooperative Centers on Human Immunology (U19 Clinical Trial Optional)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Cooperative Centers on Human Immunology (U19 Clinical Trial Optional)?
Closed April 7, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $2.5 million each.
Who has been funded under RFA-AI-22-069?
NIH RePORTER lists 9 projects funded under RFA-AI-22-069 in fiscal 2024 to 2026, at 9 institutions. The most were at La Jolla Institute for Immunology, Northwestern University, Jackson Laboratory.
Who has won Allergy and Infectious Diseases Research grants before?
The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.
Similar open grants
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- Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), Research Program (U19 Clinical Trial Optional)
- National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)
- Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)