RFA-AI-22-047: Genetic Tools for Understanding Rickettsial and Related Infections (R61/R33 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on February 14, 2023.
From the official notice on Grants.gov, last changed October 3, 2022. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR61 / R33
- Clinical trialsNot allowed
- Funded byNIAID
- Median yearly award$270,711
- Typical project length3 years
- R61, Exploratory/Developmental Phase I. The first phase of a phased award. Moving on to the R33 phase depends on meeting agreed milestones. Other open R61 notices.
- R33, Exploratory/Developmental Grant Phase II. The second phase of a phased award, usually following an R61 or R21 phase. Other open R33 notices.
Projects funded under RFA-AI-22-047 were run by National Institute of Allergy and Infectious Diseases (NIAID, 7 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AI-22-047 in the NIH Guide.
Key dates
| Posted | October 3, 2022 |
|---|---|
| Deadline | February 14, 2023 |
| Archived by Grants.gov | March 22, 2023 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the program's money (67% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
A comprehensive understanding of pathogenic bacteriology requires the ability to generate and study genetically altered bacterial strains. For the obligate intracellular human pathogens of the order Rickettsialesincluding Anaplasma, Ehrilichia, Orientia and Rickettsia speciesthese tools have long lagged behind those available for extracellular bacteria. While recent advances have demonstrated the feasibility of genetically manipulating these bacteria, inherent limitations associated with their obligate intracellular nature and reduced genomes have hindered large-scale generation of useful mutants across all species. This funding opportunity will address that research gap by dedicating support to the generation and functional characterization of mutant libraries for rickettsial species that cause infections in humans, and to the application of these new tools to better understanding the biology of rickettsial pathogens.
Funded under RFA-AI-22-047 so far
NIH funded 7 projects under RFA-AI-22-047 in fiscal 2024 to 2026, at 7 institutions. The median yearly award was $270,711.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Development of genetic tools for Orientia tsutsugamushi | Virginia Commonwealth University | 2026 | $266,917 |
| Generation and characterization of a large-scale transposon mutant library of Rickettsia parkeri | Johns Hopkins University | 2026 | $274,592 |
| Tool development for Anaplasma phagocytophilum to understand determinants of infection | Washington State University | 2026 | $251,560 |
| Development of genetic tools for overexpression and targeted mutagenesis of Orientia tsutsugamushi TPR proteins | University of Iowa | 2026 | $220,622 |
| Transposon mutagenesis of Rickettsia for studying Rickettsia-host-vector interactions | State University New York Stony Brook | 2026 | $279,125 |
| Reversible transformation of Anaplasma phagocytophilum using Cre-Lox recombination | University of Minnesota | 2026 | $264,120 |
| Generation of Orientia tsutsugamushi mutant strains for pathogenesis research | University of Texas Med BR Galveston | 2026 | $275,062 |
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AI-22-047 still open?
No. It closed on February 14, 2023.
Who can apply for Genetic Tools for Understanding Rickettsial and Related Infections (R61/R33 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Genetic Tools for Understanding Rickettsial and Related Infections (R61/R33 Clinical Trial Not Allowed)?
Closed February 14, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-AI-22-047?
NIH RePORTER lists 7 projects funded under RFA-AI-22-047 in fiscal 2024 to 2026, at 7 institutions. The most were at Virginia Commonwealth University, Johns Hopkins University, Washington State University.
Who has won Allergy and Infectious Diseases Research grants before?
The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.
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