RFA-AI-21-017: Systems Approach to Understand Mechanisms of Heterogeneous Response to Influenza (R01 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on September 8, 2021.
From the official notice on Grants.gov, last changed April 27, 2021. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR01
- Clinical trialsNot allowed
- Funded byNIAID
- Median yearly award$738,983
- Typical project length5 years
- R01, Research Project Grant. NIH's standard grant for a defined research project led by a named investigator, usually for up to five years. Other open R01 notices.
Projects funded under RFA-AI-21-017 were run by National Institute of Allergy and Infectious Diseases (NIAID, 6 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AI-21-017 in the NIH Guide.
Key dates
| Posted | April 27, 2021 |
|---|---|
| Deadline | September 8, 2021 |
| Archived by Grants.gov | October 14, 2021 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the program's money (67% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this Funding Opportunity Announcement (FOA) is to support the identification of mechanisms behind heterogeneous responses in the population to influenza infection and /or vaccination through development and application of computational tools.
Funded under RFA-AI-21-017 so far
NIH funded 6 projects under RFA-AI-21-017 in fiscal 2022 to 2026, at 6 institutions. The median yearly award was $738,983.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Deciphering the Heterogeneous Response to Influenza by a Multi-Scale Systems Approach | Icahn School of Medicine at Mount Sinai | 2026 | $631,610 |
| Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults | University of Pittsburgh at Pittsburgh | 2026 | $756,226 |
| Drivers of individual variation in influenza vaccine response and protection from infection | University of Chicago | 2026 | $1.4 million |
| Genetic Contributors to the Impact of Sex on Heterogeneity in Flu Infection | Duke University | 2026 | $450,719 |
| Identifying Influenza Virus Infection Severity and Outcome Signatures Through Artificial Intelligence-driven Analyses | J. Craig Venter Institute, Inc. | 2026 | $733,054 |
| Virtual Patient Cohorts to Illuminate Immunologic Drivers of Influenza Severity | University of Tennessee Health Sci Ctr | 2025 | $1.1 million |
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AI-21-017 still open?
No. It closed on September 8, 2021.
Who can apply for Systems Approach to Understand Mechanisms of Heterogeneous Response to Influenza (R01 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Systems Approach to Understand Mechanisms of Heterogeneous Response to Influenza (R01 Clinical Trial Not Allowed)?
Closed September 8, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-AI-21-017?
NIH RePORTER lists 6 projects funded under RFA-AI-21-017 in fiscal 2022 to 2026, at 6 institutions. The most were at Icahn School of Medicine at Mount Sinai, University of Pittsburgh at Pittsburgh, University of Chicago.
Who has won Allergy and Infectious Diseases Research grants before?
The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.
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