RFA-AI-21-012: Understanding Post-Transcriptional Regulation of Intact and Defective HIV RNA (R61/R33 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $3.0 million in total. Applications closed on August 4, 2021.
From the official notice on Grants.gov, last changed March 31, 2021. Checked November 7, 2026.
- Total funding$3.0 million
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR61 / R33
- Clinical trialsNot allowed
- Funded byNIAID
- Median yearly award$713,048
- Typical project length4 years
- R61, Exploratory/Developmental Phase I. The first phase of a phased award. Moving on to the R33 phase depends on meeting agreed milestones. Other open R61 notices.
- R33, Exploratory/Developmental Grant Phase II. The second phase of a phased award, usually following an R61 or R21 phase. Other open R33 notices.
Projects funded under RFA-AI-21-012 were run by National Institute of Allergy and Infectious Diseases (NIAID, 6 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AI-21-012 in the NIH Guide.
Key dates
| Posted | March 31, 2021 |
|---|---|
| Deadline | August 4, 2021 |
| Archived by Grants.gov | September 9, 2021 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the program's money (67% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This Funding Opportunity Announcement (FOA) encourages exploratory and developmental bi-phasic research applications to support the understanding of how HIV RNA chemical modifications impact expression of intact and defective HIV and the identification of potential therapeutic targets for future HIV cure strategies.
Funded under RFA-AI-21-012 so far
NIH funded 6 projects under RFA-AI-21-012 in fiscal 2022 to 2026, at 3 institutions. The median yearly award was $713,048.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| The role of RNA m6A modification in the regulation of HIV latency and reactivation | Case Western Reserve University | 2026 | $713,048 |
| Targeting HIV-1 RNA modifications in latently infected CD4+ T cells for therapeutic development | University of Iowa | 2026 | $736,297 |
| Coupling Epitranscriptomics to Molecular Disease Mechanisms and Nucleic Acid Therapeutics in Persistent Residual HIV Infection | Wake Forest University Health Sciences | 2026 | $747,835 |
| Targeting HIV-1 RNA modifications in latently infected CD4+ T cells for therapeutic development | University of Iowa | 2024 | $699,921 |
| Coupling Epitranscriptomics to Molecular Disease Mechanisms and Nucleic Acid Therapeutics in Persistent Residual HIV Infection | Wake Forest University Health Sciences | 2024 | $534,319 |
| The role of RNA m6A modification in the regulation of HIV latency and reactivation | Case Western Reserve University | 2024 | $715,479 |
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AI-21-012 still open?
No. It closed on August 4, 2021.
Who can apply for Understanding Post-Transcriptional Regulation of Intact and Defective HIV RNA (R61/R33 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Understanding Post-Transcriptional Regulation of Intact and Defective HIV RNA (R61/R33 Clinical Trial Not Allowed)?
Closed August 4, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
About $3.0 million in total.
Who has been funded under RFA-AI-21-012?
NIH RePORTER lists 6 projects funded under RFA-AI-21-012 in fiscal 2022 to 2026, at 3 institutions. The most were at Case Western Reserve University, University of Iowa, Wake Forest University Health Sciences.
Who has won Allergy and Infectious Diseases Research grants before?
The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.
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