RFA-AG-24-049: Artificial Intelligence in Pre-clinical Drug Development for AD/ADRD (R01 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants of up to $1.0 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $1.0 million in total. Applications closed on February 28, 2025.
From the official notice on Grants.gov, last changed January 13, 2025. Checked November 7, 2026.
- Award ceiling$1.0 million
- Total funding$1.0 million
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR01
- Clinical trialsNot allowed
- Funded byNIA
- Median yearly award$1.3 million
- Typical project length5 years
- R01, Research Project Grant. NIH's standard grant for a defined research project led by a named investigator, usually for up to five years. Other open R01 notices.
Projects funded under RFA-AG-24-049 were run by National Institute on Aging (NIA, 5 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AG-24-049 in the NIH Guide.
Key dates
| Posted | December 2, 2024 |
|---|---|
| Deadline | February 28, 2025 |
| Archived by Grants.gov | March 30, 2025 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $1.3 million; it allows up to $1.0 million per award.
- Most of the program's money (73% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This NOFO invites applications that apply existing or newly developed artificial intelligence and machine learning methods (AI/ML) to various aspects of drug discovery and preclinical drug development to accelerate the identification, optimization, and selection of preclinical drug candidates for the treatment and prevention of Alzheimers disease (AD) and AD-related dementias ADRD and increase their likelihood of success during clinical drug development. This program will also create advanced open-source analytical tools that will be made available to researchers in academia and biotech/pharma for more effective prosecution of AD/ADRD drug discovery campaigns for novel targets.
Funded under RFA-AG-24-049 so far
NIH funded 5 projects under RFA-AG-24-049 in fiscal 2026, at 5 institutions. The median yearly award was $1.3 million.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| AI Driven Drug Discovery Pipeline for Lead Optimization: from Virtual Screening to Preclinical Validation of Brain-Penetrant AD Therapeutics | Trustees of Indiana University | 2026 | $1.2 million |
| Integration of artificial intelligence and drug discovery to treat Alzheimer’s disease | Univ of North Carolina Chapel Hill | 2026 | $1.3 million |
| Generative Peptide Drug Design for AD/ADRD | Purdue University | 2026 | $1.3 million |
| AI-driven discovery of in vivo chemical probes for understudied targets for the treatment of Alzheimer's disease and related disorders (ADRD) | Fox Chase Chemical Diversity Center, Inc | 2026 | $1.1 million |
| Using DNA-Encoded Chemical Libraries to Enable Machine Learning for Alzheimer's Disease Drug Discovery | Baylor College of Medicine | 2026 | $1.3 million |
Who has won Aging Research grants before
From fiscal 2021 to 2025, Aging Research (93.866) awarded $19 billion across 11,026 grant awards, an average of $1.7 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Regents of the University of California, San Francisco | California | 337 | $575 million |
| The Trustees of Columbia University in the City of New York | New York | 242 | $574 million |
| University of Southern California | California | 203 | $572 million |
| The Washington University | Missouri | 210 | $556 million |
| Regents of the University of Michigan | Michigan | 232 | $538 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AG-24-049 still open?
No. It closed on February 28, 2025.
Who can apply for Artificial Intelligence in Pre-clinical Drug Development for AD/ADRD (R01 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Artificial Intelligence in Pre-clinical Drug Development for AD/ADRD (R01 Clinical Trial Not Allowed)?
Closed February 28, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $1.0 million each. About $1.0 million in total.
Who has been funded under RFA-AG-24-049?
NIH RePORTER lists 5 projects funded under RFA-AG-24-049 in fiscal 2026, at 5 institutions. The most were at Trustees of Indiana University, Univ of North Carolina Chapel Hill, Purdue University.
Who has won Aging Research grants before?
The largest recipients over five fiscal years were The Regents of the University of California, San Francisco, The Trustees of Columbia University in the City of New York, University of Southern California. The program made 11,026 awards worth $19 billion in that time.
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