PAR-25-300: Targeting Cell Surface HIV Envelope for Cell Elimination (R01 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on February 19, 2026.
From the official notice on Grants.gov, last changed February 19, 2026. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR01
- Clinical trialsNot allowed
- Funded byNIAID
- Median yearly award$935,291
- Typical project length5 years
- R01, Research Project Grant. NIH's standard grant for a defined research project led by a named investigator, usually for up to five years. Other open R01 notices.
Projects funded under PAR-25-300 were run by National Institute of Allergy and Infectious Diseases (NIAID, 4 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-25-300 in the NIH Guide.
Key dates
| Posted | December 2, 2024 |
|---|---|
| Deadline | February 19, 2026 |
| Archived by Grants.gov | March 21, 2026 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the program's money (67% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this notice of funding opportunity (NOFO) is to support the investigation of HIV-1 Envelope (Env) cell surface expression, the structural mechanism of biologic-mediated cell killing, and the development of novel approaches to enhance the recognition and elimination of Env-expressing, HIV-1 infected cells. These studies are expected to inform the development of immunotherapies and targeted vaccines for HIV-1 prevention and cure.
Funded under PAR-25-300 so far
NIH funded 4 projects under PAR-25-300 in fiscal 2026, at 4 institutions. The median yearly award was $935,291.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Nanoscale imaging of cell surface HIV Env immune complexes to optimize NK cell ADCC antibody therapeutics | San Diego Biomedical Research Institute | 2026 | $992,920 |
| Optimizing engineered T cells with highly sensitive anti-HIV/Env HLA-independent T cell receptors (HITs) | University of California, San Francisco | 2026 | $3.3 million |
| High Avidity Multiepitope Targeting of RNA-induced cell surface HIV Env | Icahn School of Medicine at Mount Sinai | 2026 | $832,773 |
| Biomechanical and Epigenetic Determinants of CTL Resistance in HIV Reservoirs | Weill Medical Coll of Cornell Univ | 2026 | $877,662 |
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-25-300 still open?
No. It closed on February 19, 2026.
Who can apply for Targeting Cell Surface HIV Envelope for Cell Elimination (R01 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Targeting Cell Surface HIV Envelope for Cell Elimination (R01 Clinical Trial Not Allowed)?
Closed February 19, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under PAR-25-300?
NIH RePORTER lists 4 projects funded under PAR-25-300 in fiscal 2026, at 4 institutions. The most were at San Diego Biomedical Research Institute, University of California, San Francisco, Icahn School of Medicine at Mount Sinai.
Who has won Allergy and Infectious Diseases Research grants before?
The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.
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