PAR-25-156: Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science (RC2 Clinical Trials Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants to colleges and universities. Applications closed on September 28, 2026.
From the official notice on Grants.gov, last changed March 26, 2025. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeRC2
- Clinical trialsOptional
- Funded byNCATS
- Median yearly award$3.2 million
- Typical project length4 years
Projects funded under PAR-25-156 were run by National Center for Advancing Translational Sciences (NCATS, 3 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-25-156 in the NIH Guide.
Key dates
| Posted | December 10, 2024 |
|---|---|
| Deadline | September 28, 2026 |
| Archived by Grants.gov | November 3, 2026 |
Who can apply
This opportunity was open to colleges and universities.
- Public and State controlled institutions of higher education
Other Eligible Applicants include the following:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Most of the program's money (82% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of the High Impact Specialized Innovation Programs (SIPs) is to support the development and demonstration of unique hub capabilities, research platforms and/or resources to address in a timely manner critical gap areas and/or roadblocks in clinical and translational science at awarded UM1 Clinical and Translational Science Awards (CTSA) Program Hubs (PAR-24-272). Successful programs supported through this funding opportunity are expected to lay a strong foundation for future adoption and/or dissemination of capabilities to additional CTSA Program Hubs.
Funded under PAR-25-156 so far
NIH funded 3 projects under PAR-25-156 in fiscal 2026, at 3 institutions. The median yearly award was $3.2 million.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| A Novel Machine Learning-Enabled Metabolic Imaging Platform for Physiologically Relevant, Predictive Drug Efficacy Testing | University of California-Irvine | 2026 | $3.0 million |
| Research Redesign to Reduce Chronic Conditions in Families | University of Pennsylvania | 2026 | $3.3 million |
| Accelerating Translation from Comparative Effectiveness through Implementation and Dissemination in Acute Care Medicine (ACTIVATE) Platform | Albert Einstein College of Medicine | 2026 | $3.2 million |
Who has won National Center for Advancing Translational Sciences grants before
From fiscal 2021 to 2025, National Center for Advancing Translational Sciences (93.350) awarded $3.1 billion across 867 grant awards, an average of $3.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 15 | $95.3 million |
| Vanderbilt University Medical Center | Tennessee | 10 | $94.6 million |
| Duke University | North Carolina | 11 | $88.9 million |
| University of North Carolina at Chapel Hill | North Carolina | 16 | $74.5 million |
| The Johns Hopkins University | Maryland | 20 | $70.7 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-25-156 still open?
No. It closed on September 28, 2026.
Who can apply for Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science (RC2 Clinical Trials Optional)?
National Institutes of Health accepted applications from colleges and universities. The notice adds further conditions, so read its eligibility section.
What is the deadline for Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science (RC2 Clinical Trials Optional)?
Closed September 28, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under PAR-25-156?
NIH RePORTER lists 3 projects funded under PAR-25-156 in fiscal 2026, at 3 institutions. The most were at University of California-Irvine, University of Pennsylvania, Albert Einstein College of Medicine.
Who has won National Center for Advancing Translational Sciences grants before?
The largest recipients over five fiscal years were University of Pittsburgh - of the Commonwealth System of Higher Education, Vanderbilt University Medical Center, Duke University. The program made 867 awards worth $3.1 billion in that time.
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