PAR-23-288: NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Basic Experimental Studies with Humans Required)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2023.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on May 24, 2026.
From the official notice on Grants.gov, last changed April 21, 2026. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- K99, Pathway to Independence Award. A mentored postdoctoral phase that leads into the independent R00 phase. Other open K99 notices.
- R00, Research Transition Award. The independent phase of the K99/R00 Pathway to Independence award. Other open R00 notices.
Application due dates, page limits and budget limits are set in the notice. Read PAR-23-288 in the NIH Guide.
Key dates
| Posted | November 8, 2023 |
|---|---|
| Deadline | May 24, 2026 |
| Archived by Grants.gov | June 23, 2026 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Required Registrations
Is this a realistic fit?
- Most of the program's money (72% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of the NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00) program is to increase and maintain a strong cohort of new and talented, NCI-supported, independent investigators. This program is designed for postdoctoral fellows with research and/or clinical doctoral degrees who do not require an extended period of mentored research training beyond their doctoral degrees. The objective of this award is to facilitate a timely transition of these fellows from their mentored, postdoctoral research positions to independent tenure-track (or equivalent) faculty positions. The program will provide independent NCI research support during this transition to help awardees to launch competitive, independent research careers. Researchers in the scientific areas of cancer control, cancer prevention and cancer data sciences are especially encouraged to work with their institutions to apply. This notice of funding opportunity (NOFO) is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should be submitted under this NOFO include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Those not planning an independent clinical trial or basic experimental study with humans, or proposing to gain research experience in a clinical trial or basic experimental study with humans led by another investigator, must apply to the 'Independent Clinical Trial Not Allowed' companion NOFO (PAR-23-286).
Who has won Cancer Research Manpower grants before
From fiscal 2021 to 2025, Cancer Research Manpower (93.398) awarded $1.0 billion across 2,913 grant awards, an average of $359,612 per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Sloan-Kettering Institute for Cancer Research | New York | 92 | $52.8 million |
| Dana-Farber Cancer Institute, Inc. | Massachusetts | 100 | $38.4 million |
| The Univeristy of Texas M.D. Anderson Cancer Center | Texas | 65 | $35.5 million |
| The General Hospital Corporation | Massachusetts | 58 | $35.4 million |
| The Johns Hopkins University | Maryland | 69 | $33.7 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-23-288 still open?
No. It closed on May 24, 2026.
Who can apply for NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Basic Experimental Studies with Humans Required)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Basic Experimental Studies with Humans Required)?
Closed May 24, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has won Cancer Research Manpower grants before?
The largest recipients over five fiscal years were Sloan-Kettering Institute for Cancer Research, Dana-Farber Cancer Institute, Inc., The Univeristy of Texas M.D. Anderson Cancer Center. The program made 2,913 awards worth $1.0 billion in that time.
Similar open grants
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Mentored Career Transition Award (KT1/R00)
- NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)
- NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)