PAR-22-215: Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants of up to $499,999 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on November 5, 2024.
From the official notice on Grants.gov, last changed November 6, 2024. Checked November 7, 2026.
- Award ceiling$499,999
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR01
- Clinical trialsNot allowed
- Funded byNICHD
- Median yearly award$591,324
- Typical project length5 years
- R01, Research Project Grant. NIH's standard grant for a defined research project led by a named investigator, usually for up to five years. Other open R01 notices.
Projects funded under PAR-22-215 were run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, 5 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-22-215 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| PAR-25-146 | November 6, 2024 | Closed September 7, 2025 | Closed |
Key dates
| Posted | August 9, 2022 |
|---|---|
| Deadline | November 5, 2024 |
| Archived by Grants.gov | December 5, 2024 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $591,324; it allows up to $499,999 per award.
- Most of the program's money (72% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this funding opportunity announcement (FOA) is to support innovative research that will inform our understanding of the mechanisms underlying the formation of structural birth defects using animal models in conjunction with human translational/clinical approaches. Applicants are encouraged to take advantage of advances in genetics, omics methods (genomics, proteomics, metabolomics, etc.), and synthetic biology, biochemical and other approaches to developmental biology research to identify specific genetic, epigenetic, environmental, or gene/environment interactions associated with the formation of, susceptibility to, and variability of structural birth defects in human populations.
Funded under PAR-22-215 so far
NIH funded 5 projects under PAR-22-215 in fiscal 2023 to 2026, at 5 institutions. The median yearly award was $591,324.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Biomimetic intervention strategies for endogenous in utero repair of Spina Bifida | Baylor College of Medicine | 2026 | $580,204 |
| Impact of maternal dietary vitamin A on risk and severity of cleft lip/palate in genetically sensitized embryos | University of Missouri Kansas City | 2026 | $336,475 |
| Dysregulated RNA metabolism in cell fate of maternal diabetes-induced neural tube defects | University of Maryland Baltimore | 2026 | $668,211 |
| Gene x Environment Interactions and Congenital Heart Defects – Illuminating the Mechanisms | Children's Research Institute | 2026 | $540,360 |
| Functional Validation of Novel Variants Associated with Congenital Diaphragmatic Hernia | Jackson Laboratory | 2026 | $737,356 |
Who has won Child Health and Human Development Extramural Research grants before
From fiscal 2021 to 2025, Child Health and Human Development Extramural Research (93.865) awarded $6.0 billion across 6,026 grant awards, an average of $1.0 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Regents of the University of Michigan | Michigan | 167 | $178 million |
| The Johns Hopkins University | Maryland | 133 | $146 million |
| University of Washington | Washington | 114 | $131 million |
| Baylor College of Medicine | Texas | 116 | $124 million |
| The Leland Stanford Junior University | California | 104 | $116 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-22-215 still open?
No. It closed on November 5, 2024.
Who can apply for Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed)?
Closed November 5, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $499,999 each.
Who has been funded under PAR-22-215?
NIH RePORTER lists 5 projects funded under PAR-22-215 in fiscal 2023 to 2026, at 5 institutions. The most were at Baylor College of Medicine, University of Missouri Kansas City, University of Maryland Baltimore.
Who has won Child Health and Human Development Extramural Research grants before?
The largest recipients over five fiscal years were Regents of the University of Michigan, The Johns Hopkins University, University of Washington. The program made 6,026 awards worth $6.0 billion in that time.
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