Grants / Department of Defense / Defense Health Agency Contracting Activity - DHACA

HT9425-23-ALSRP-TDA: DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award

Closed Closed July 13, 2023 Opportunity HT9425-23-ALSRP-TDA ☆ Save

This grant is closed. A newer notice from the same program is open now: DoW Breast Cancer, Clinical Research Extension Award (HT942526BCRPCREA2). Status: Closes November 18, 2026 (11 days left). It is in our archive of Defense Health Agency Contracting Activity - DHACA notices from 2023.

• Total funding$9.6 million
• Expected awards4
• Cost sharingNot required
• Funding typeCooperative Agreement, Grant

Key dates

Who can apply

This opportunity was open to any type of organization.

• Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses, individuals.

Is this a realistic fit?

• Most of the program's money (59% over five years) went to colleges and universities.
• No cost sharing or match is required.

What the grant funds

The FY23 ALSRP Therapeutic Development Award supports research ranging from preclinical validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product driven. Applicants with limited ALS experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints, and pathophysiology. Examples of activities that will be supported by this award include: Confirmation of candidate therapeutics obtained from screening or by other means, including optimization of potency and pharmacological properties and testing of derivatives and sister compounds. Validation of pilot efficacy studies (such as from an ALSRP Therapeutic Idea Award), including the use of additional ALS model systems and/or replicating preliminary data with more time points or additional doses. IND-enabling studies to include: compound characterization; absorption, distribution, metabolism, and excretion (ADME) studies; studies on formulation and stability leading to Good Manufacturing Practice production methods; dose/response and toxicology studies in relevant model systems. Applications supported by this award must begin with lead compounds in hand and must include preliminary data relevant to the phase of development, such as: Proof of identity and purity Selectivity for the intended target over closely related targets Availability of primary and secondary in vitro bioactivity assays for optimization or structure–activity relationship studies Availability of clear efficacy data in at least one relevant preclinical Amyotrophic Lateral Sclerosis (ALS) model, with adequate power and methods. Applicants seeking support for basic research focused on ALS drug discovery are encouraged to apply for the FY23 ALSRP Therapeutic Idea Award (Funding Opportunity Number HT9425-23-ALSRP-TIA), which does not require preliminary data (https://cdmrp.health.mil/funding/alsrp).

Category: Science and Technology and other Research and Development.

Applying now

This notice no longer takes applications. Apply under the newer notice, HT942526BCRPCREA2, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.