HR001124S0032: Broad-Spectrum Antagonists For Editors (B-SAFE)
Closed
This grant is closed. A newer notice from the same program is open now: Young Faculty Award (YFA) 2027 (DARPARA2701). Status: Closes January 13, 2027 (67 days left). It is in our archive of DARPA - Biological Technologies Office notices from 2024.
DARPA - Biological Technologies Office offered grants to the applicants described in the notice. Applications closed on August 12, 2024.
From the official notice on Grants.gov, last changed July 3, 2024. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeCooperative Agreement, Other, Procurement Contract
Key dates
| Posted | June 14, 2024 |
|---|---|
| Deadline | August 12, 2024 |
| Archived by Grants.gov | September 11, 2024 |
Who can apply
This opportunity was open to the applicants described in the notice.
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information.
Is this a realistic fit?
- Most of the program's money (93% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to identify and optimize novel molecules that exhibit inhibitory effects on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated proteins (CRISPR-Cas) gene editing processes. The Broad-Spectrum Antagonists for Editors (B-SAFE) program is explicitly seeking transformative approaches enabling the discovery or design of novel inhibitors of gene editing technologies with enhanced activity, utility, and breadth of coverage. Novel inhibitor activity will be assessed in vitro over the course of the program and a subset of top performing molecules will be selected for scale-up at quantities sufficient for testing and evaluation by Department of Defense (DoD) stakeholders. In concert, DARPA is interested in exploring methods to rapidly discover inhibitor molecules for novel gene editing technologies beyond CRISPR-Cas systems to keep pace with the rapidly advancing field and promote the safe, controlled use of these technologies. Research that generates incremental improvements to the existing state-of-the-art are specifically excluded.
Who has won Research and Technology Development grants before
From fiscal 2021 to 2025, Research and Technology Development (12.910) awarded $1.5 billion across 739 grant awards, an average of $2.1 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| University of Southern California | California | 26 | $84.5 million |
| Clemson University | South Carolina | 2 | $82.2 million |
| Massachusetts Institute of Technology | Massachusetts | 29 | $63.1 million |
| Regents of the University of Michigan | Michigan | 21 | $59.6 million |
| The Regents of the University of California, San Francisco | California | 5 | $44.4 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, DARPARA2701, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is HR001124S0032 still open?
No. It closed on August 12, 2024. A newer notice is open: DARPARA2701, closes January 13, 2027 (67 days left).
Who can apply for Broad-Spectrum Antagonists For Editors (B-SAFE)?
DARPA - Biological Technologies Office accepted applications from the applicants described in the notice. The notice adds further conditions, so read its eligibility section.
What is the deadline for Broad-Spectrum Antagonists For Editors (B-SAFE)?
Closed August 12, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has won Research and Technology Development grants before?
The largest recipients over five fiscal years were University of Southern California, Clemson University, Massachusetts Institute of Technology. The program made 739 awards worth $1.5 billion in that time.