HR001121S0038: Reimagining Protein Manufacturing (RPM)
Closed
This grant is closed. A newer notice from the same program is open now: Young Faculty Award (YFA) 2027 (DARPARA2701). Status: Closes January 13, 2027 (67 days left). It is in our archive of DARPA - Biological Technologies Office notices from 2021.
DARPA - Biological Technologies Office offered grants to the applicants described in the notice. Applications closed on November 16, 2021.
From the official notice on Grants.gov, last changed August 23, 2021. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeCooperative Agreement, Grant, Other, Procurement Contract
Key dates
| Posted | August 23, 2021 |
|---|---|
| Deadline | November 16, 2021 |
| Archived by Grants.gov | December 16, 2021 |
Who can apply
This opportunity was open to the applicants described in the notice.
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information.
Is this a realistic fit?
- Most of the program's money (93% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The Reimagining Protein Manufacturing (RPM) program aims to ensure timely DoD access to critical medical countermeasures (MCMs) by establishing the foundational technologies needed for fully distributed, on-demand manufacturing of protein-based MCMs and associated raw materials. To achieve this goal, RPM will develop technologies to enable immediate synthesis (lead time approximately 24 hours) of bioactive protein MCMs and raw material production enzymes at a yield corresponding to > 500 doses per week. This technology will allow the DoD to rapidly secure access to both therapeutic proteins and enzymes needed for nucleic acid-based MCM synthesis, and reduce reliance on complex supply chains.
Who has won Research and Technology Development grants before
From fiscal 2021 to 2025, Research and Technology Development (12.910) awarded $1.5 billion across 739 grant awards, an average of $2.1 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| University of Southern California | California | 26 | $84.5 million |
| Clemson University | South Carolina | 2 | $82.2 million |
| Massachusetts Institute of Technology | Massachusetts | 29 | $63.1 million |
| Regents of the University of Michigan | Michigan | 21 | $59.6 million |
| The Regents of the University of California, San Francisco | California | 5 | $44.4 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, DARPARA2701, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is HR001121S0038 still open?
No. It closed on November 16, 2021. A newer notice is open: DARPARA2701, closes January 13, 2027 (67 days left).
Who can apply for Reimagining Protein Manufacturing (RPM)?
DARPA - Biological Technologies Office accepted applications from the applicants described in the notice. The notice adds further conditions, so read its eligibility section.
What is the deadline for Reimagining Protein Manufacturing (RPM)?
Closed November 16, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has won Research and Technology Development grants before?
The largest recipients over five fiscal years were University of Southern California, Clemson University, Massachusetts Institute of Technology. The program made 739 awards worth $1.5 billion in that time.