Grants / Department of Energy / Office of Science

DE-FOA-0002878: Integrative Computational Tools for Systems Biology Research

Closed Closed March 30, 2023 Opportunity DE-FOA-0002878 ☆ Save

This grant is closed. A newer notice from the same program is open now: Genesis Mission Graduate Fellowship Pilot (DE-FOA-0003673). Status: Closes January 12, 2027 (66 days left). It is in our archive of Office of Science notices from 2022.

• Award ceiling$1.1 million
• Award floor$300,000
• Total funding$5.0 million
• Cost sharingNot required
• Funding typeGrant

Key dates

Who can apply

This opportunity was open to any type of organization.

• Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

All types of domestic applicants are eligible to apply, except nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code of 1986 that engaged in lobbying activities after December 31, 1995.Federally affiliated entities must adhere to the eligibility standards below:1. DOE/NNSA National LaboratoriesDOE/NNSA National Laboratories are not eligible to submit applications under this FOA but may be proposed as subrecipients under another organization’s application. If recommended for funding as a proposed subrecipient, the value of the proposed subaward will be removed from the prime applicant’s award and will be provided to the laboratory through the DOE Field-Work Proposal System and work will be conducted under the laboratory’s contract with DOE. No administrative provisions of this FOA will apply to the laboratory or any laboratory subcontractor. Additional instructions for securing authorization from the cognizant Contracting Officer are found in Section VIII of this FOA.2. Non-DOE/NNSA FFRDCsNon-DOE/NNSA FFRDCs are not eligible to submit applications under this FOA but may be proposed as subrecipients under another organization’s application. If recommended for funding as a proposed subrecipient, the value of the proposed subaward may be removed from the prime applicant’s award and may be provided through an interagency agreement to the FFRDC’s sponsoring Federal Agency. Additional instructions for securing authorization from the cognizant Contracting Officer are found in Section VIII of this FOA.3. Other Federal AgenciesOther Federal Agencies are not eligible to submit applications under this FOA but may be proposed as subrecipients under another organization’s application. If recommended for funding as a proposed subrecipient, the value of the proposed subaward may be removed from the prime applicant’s award and may be provided through an interagency agreement. Additional instructions for providing statutory authorization are found in Section VIII of this FOA.

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Is this a realistic fit?

• Past Office of Science Financial Assistance Program awards averaged $1.2 million; this notice allows up to $1.1 million per award.
• Most of the program's money (69% over five years) went to colleges and universities.
• No cost sharing or match is required.

What the grant funds

The BER program supports basic research to understand the fundamental nature of biological processes relevant to DOE energy and environmental mission goals. Within BER, the GSP supports systems biology research on microbial, plant, plant-microbe interactions, and environmental microbial communities to address DOE’s mission in sustainable bioenergy development. Understanding and harnessing the metabolic and regulatory networks of plants and microbes will enable their design and re-engineering for improved energy resilience and sustainability, including advanced biofuels and bio products. The widespread adoption of high-throughput, multi-omic techniques has revolutionized biological research, enabling a broader view and deeper understanding of cellular processes and the biological systems they drive. In pursuit of predictive modeling and genome-scale engineering of complex biological systems important for bioenergy, the research supported by the GSP generates vast amounts of complex omic’ and other data from a wide range of analytical technologies and experimental approaches. These data span multiple spatio-temporal scales, reflecting the organizational complexities of biological systems, and present significant computational challenges for identifying causal variants that influence phenotype. Accurate modeling of the underlying systems biology depends on surmounting those challenges. The collective characterization and quantification of pools of biological molecules (genomics, transcriptomics, proteomics, metabolomics) and their systems processes are essential to construct coherent knowledge of the systems underpinning and governing the diverse phenomics and functioning of plants, microbes, and their communities. Such characterizations necessitate the ability to combine data sets of heterogeneous types, integrated over time and space, and to represent emergent relationships in a coherent framework. The breadth of data types and the complexities inherent in the integration of different data layers present significant conceptual and implementation challenges. New algorithms for incorporating data derived from innovations in genomics, molecular imaging, structural biology, and spectroscopy are needed to work effectively with, and glean useful insights from, complex, integrated molecular, -omics’ data.

Category: Science and Technology and other Research and Development.

Applying now

This notice no longer takes applications. Apply under the newer notice, DE-FOA-0003673, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.