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Grants / Department of Health and Human Services / Advanced Research Projects Agency for Health

ARPA-H-SOL-24-106: Proactive Health Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health

Closed Closed March 14, 2025 Opportunity ARPA-H-SOL-24-106

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of Advanced Research Projects Agency for Health notices from 2024.

Advanced Research Projects Agency for Health offered grants to nonprofits, colleges and universities, tribes, small businesses and businesses. Applications closed on March 14, 2025.

From the official notice on Grants.gov, last changed March 26, 2024. Checked November 7, 2026.

Key dates

PostedMarch 14, 2024
DeadlineMarch 14, 2025
Archived by Grants.govApril 13, 2025

Who can apply

This opportunity was open to nonprofits, colleges and universities, tribes, small businesses and businesses.

All 7 applicant types the notice lists

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Is this a realistic fit?

What the grant funds

Despite huge advances in the development of novel medical therapies, Americans still live with poor health outcomes and suffer from the ill-effects of disease. Current medical research and the medical delivery system in the United States focus primarily on the reactive treatment of illnesses, despite the fact that many diseases or their ill-effects are preventable. The Proactive Health Office (PHO) at ARPA-H is seeking solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness. Specifically, PHO hypothesizes that 1) population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors and 2) development of novel early-detection methods and prophylactic interventions could drastically improve the health of American throughout their lives, and 3) that system level innovations are required for delivery of proactive health effectively. Specific PHO interest areas include: Novel prevention, detection and prophylactic treatment methods for disease: • Novel and scalable methods for early detection of disease and illness including the use of low/no-cost sensing modalities. • Prophylactic approaches to prevention of diseases and harmful disease outcomes. • Methods for continuous and widespread sensing of health state and early disease indicators that can be deployed at population-scale. Population-level approaches to increase the adoption of prevention and wellness behaviors: • Early indicators of disease and pre-disease states and measures associated with proactive health outcomes that are both inexpensive and effective. Low-cost, high-uptake mental health resiliency and mindfulness building methods for individuals. • Methods to inform and educate individuals about healthy behaviors including lifestyle and preventative medical measures. • Methods that incentivize individuals to adopt and maintain healthy behaviors. • Novel approaches to increasing individual healthspan and independence even in the absence of disease. System innovation for the delivery of proactive health outcomes: • Novel, robust and predictive surrogates for long-term health outcomes with associated epidemiological models. • Valuation models for long-term treatment effects for vaccination, screening and other public health interventions. • New funding and delivery models for preventative intervention.

Category: Health, Science and Technology and other Research and Development.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before

From fiscal 2021 to 2025, ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) (93.384) awarded $524 million across 42 grant awards, an average of $12.5 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of California, San FranciscoCalifornia3$51.9 million
Vanderbilt University Medical CenterTennessee2$39.8 million
University of WashingtonWashington2$38.9 million
William Marsh Rice UniversityTexas2$35.4 million
Emory UniversityGeorgia2$33.7 million

Top states: California ($135 million), Texas ($62.0 million), Massachusetts ($48.9 million), Tennessee ($45.9 million), Washington ($38.9 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is ARPA-H-SOL-24-106 still open?

No. It closed on March 14, 2025.

Who can apply for Proactive Health Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health?

Advanced Research Projects Agency for Health accepted applications from nonprofits, colleges and universities, tribes, small businesses and businesses.

What is the deadline for Proactive Health Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health?

Closed March 14, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before?

The largest recipients over five fiscal years were The Regents of the University of California, San Francisco, Vanderbilt University Medical Center, University of Washington. The program made 42 awards worth $524 million in that time.

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