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Grants / Department of Health and Human Services / Advanced Research Projects Agency for Health

ARPA-H-SOL-24-104: Health Science Futures: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health

Closed Closed March 14, 2025 Opportunity ARPA-H-SOL-24-104

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of Advanced Research Projects Agency for Health notices from 2024.

Advanced Research Projects Agency for Health offered grants to nonprofits, colleges and universities, tribes, small businesses and businesses. It expected to make about 100 awards. Applications closed on March 14, 2025.

From the official notice on Grants.gov, last changed March 26, 2024. Checked November 7, 2026.

Key dates

PostedMarch 14, 2024
DeadlineMarch 14, 2025
Archived by Grants.govApril 13, 2025

Who can apply

This opportunity was open to nonprofits, colleges and universities, tribes, small businesses and businesses.

All 7 applicant types the notice lists

More grants for nonprofits, colleges and universities, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Considering the current healthcare challenges that we face today, the goal of achieving better health outcomes is a moving target that requires daring and adaptable solutions. HSF awardees will develop innovative technologies, tools, and platforms that can be applied to a broad range of diseases. The following interest areas define the ground-breaking research we seek to support: Breakthrough Technologies: Paradigm shifting technologies that will change how we approach the diagnosis, treatment, and impact of diseases and conditions. • Novel approaches to improve maternal and fetal medicine, decrease maternal morbidity and mortality during birth, and the post-partum period. Efforts should include new technology to monitor, detect, and/or treat maternal and/or fetal complications with less invasive and traumatic methods. • Foundational advances in genetic, epigenetic, cellular, tissue, and organ replacement therapies that enable personalized medical interventions at scale in a manner that is accessible, cost-effective, and designed to impact the communities of greatest need. • Interventions that target and reverse disease pathogenesis and/or enhance plasticity to address diseases of the nervous, neuromuscular, skeletal, lymphatic, cardiovascular, and other organ systems. • Novel approaches to diagnose and treat diseases of the lymphatic system, particularly rare diseases, with a focus on the effects of genetic expression in the lymphatic system and/or models demonstrating the relationship between lymphatic dysfunction and health and disease. Transformative Tools: Novel, agile solutions that will move from bench to bedside quickly, facilitating revolutionary advances in medical care. • Development of tools that counter idiosyncratic, off-target, or chronic effects of medicines that are commonly used or that are being used experimentally to treat or prevent disease. • Development of bionics to restore sight, hearing, taste, or smell.

Category: Health, Science and Technology and other Research and Development.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before

From fiscal 2021 to 2025, ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) (93.384) awarded $524 million across 42 grant awards, an average of $12.5 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of California, San FranciscoCalifornia3$51.9 million
Vanderbilt University Medical CenterTennessee2$39.8 million
University of WashingtonWashington2$38.9 million
William Marsh Rice UniversityTexas2$35.4 million
Emory UniversityGeorgia2$33.7 million

Top states: California ($135 million), Texas ($62.0 million), Massachusetts ($48.9 million), Tennessee ($45.9 million), Washington ($38.9 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is ARPA-H-SOL-24-104 still open?

No. It closed on March 14, 2025.

Who can apply for Health Science Futures: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health?

Advanced Research Projects Agency for Health accepted applications from nonprofits, colleges and universities, tribes, small businesses and businesses.

What is the deadline for Health Science Futures: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health?

Closed March 14, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before?

The largest recipients over five fiscal years were The Regents of the University of California, San Francisco, Vanderbilt University Medical Center, University of Washington. The program made 42 awards worth $524 million in that time.

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