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Grants / Department of Health and Human Services / Advanced Research Projects Agency for Health

ARPA-H-SOL-24-103: Resilient Systems Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health

Closed Closed March 14, 2025 Opportunity ARPA-H-SOL-24-103

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of Advanced Research Projects Agency for Health notices from 2024.

Advanced Research Projects Agency for Health offered grants to nonprofits, colleges and universities, tribes, small businesses and businesses. It expected to make about 100 awards. Applications closed on March 14, 2025.

From the official notice on Grants.gov, last changed March 26, 2024. Checked November 7, 2026.

Key dates

PostedMarch 14, 2024
DeadlineMarch 14, 2025
Archived by Grants.govApril 13, 2025

Who can apply

This opportunity was open to nonprofits, colleges and universities, tribes, small businesses and businesses.

All 7 applicant types the notice lists

More grants for nonprofits, colleges and universities, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

This ISO seeks solution summary and proposal submissions for projects that fall within the scope of the ARPA-H mission Resilient Systems Office (RSO). RSO’s interest areas will address systemic challenges across the healthcare and public health landscape by investing in cutting-edge technologies that address long-standing gaps in the quality, efficacy, and consistent availability of care. Aspects of today’s health and public health systems remain fragile due to systemic challenges, which include rising healthcare costs, inadequate healthcare coverage for significant populations, outdated infrastructure, and health disparities among different demographic groups. Acute challenges, such as hospital closures, supply chain disruptions, staffing shortages, cyber-attacks, public health crises, and the emergence of new diseases, further exacerbate existing fragilities, making it more difficult to maintain high standards of care. These challenges are compounded by the fact that systems remain fragmented, hindering the ability to gain comprehensive insights, make informed decisions, develop tailored interventions, and share critical health information between stakeholders. RSO seeks solution summaries and proposals that drive innovations to enhance the adaptability, reliability, and interoperability of the health ecosystem. Of interest are innovations that foster flexibility and enable adaptation to system stressors, so that people and systems remain well-positioned to deliver high-quality care and improve health outcomes. The following interest areas categorize the ground-breaking research we seek to support: Sociotechnical System Innovation: • Innovate user-centric digital health tools, platforms, technologies, and intervention models that improve outcomes across the health continuum, including prevention, diagnosis, and treatment of physical, mental, and behavioral health. • Approaches to build trust in the healthcare system and distribute high-quality health guidance in an understandable manner that improves patient outcomes. • Novel real-time measurement tools to track health outcomes, evaluate post-market performance of new interventions, and enable convergence on the most effective strategies to improve the quality of care, especially for underserved communities. • Other population centered innovations to create more resilient communities and subpopulations.

Category: Health, Science and Technology and other Research and Development.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before

From fiscal 2021 to 2025, ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) (93.384) awarded $524 million across 42 grant awards, an average of $12.5 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of California, San FranciscoCalifornia3$51.9 million
Vanderbilt University Medical CenterTennessee2$39.8 million
University of WashingtonWashington2$38.9 million
William Marsh Rice UniversityTexas2$35.4 million
Emory UniversityGeorgia2$33.7 million

Top states: California ($135 million), Texas ($62.0 million), Massachusetts ($48.9 million), Tennessee ($45.9 million), Washington ($38.9 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is ARPA-H-SOL-24-103 still open?

No. It closed on March 14, 2025.

Who can apply for Resilient Systems Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health?

Advanced Research Projects Agency for Health accepted applications from nonprofits, colleges and universities, tribes, small businesses and businesses.

What is the deadline for Resilient Systems Office: Office-Wide Innovative Solutions Opening for Advanced Research Projects Agency for Health?

Closed March 14, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before?

The largest recipients over five fiscal years were The Regents of the University of California, San Francisco, Vanderbilt University Medical Center, University of Washington. The program made 42 awards worth $524 million in that time.

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