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Grants / Department of Health and Human Services / Advanced Research Projects Agency for Health

ARPA-H-MAI-24-01: Master Announcement Instructions (MAI)

Closed Closed December 31, 2024 Opportunity ARPA-H-MAI-24-01

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of Advanced Research Projects Agency for Health notices from 2023.

Advanced Research Projects Agency for Health offered grants to the applicants described in the notice. Applications closed on December 31, 2024.

From the official notice on Grants.gov, last changed September 20, 2024. Checked November 7, 2026.

Key dates

PostedOctober 20, 2023
DeadlineDecember 31, 2024
Archived by Grants.govJanuary 15, 2025

Who can apply

This opportunity was open to the applicants described in the notice.

See solicitation eligibility requirements

Is this a realistic fit?

What the grant funds

Amendment 2 (September 20, 2024): The purpose of this Amendment is to extend the Master Announcement Instructions (MAI) Closing Date from October 20, 2024 until December 31, 2024. All changes are highlighted in yellow. Please see Amendment 2 attachment for further details. Amendment 1 (June 25, 2024): The purpose of this Amendment 1 is to: 1) make administrative updates to Section 1.1, 1.2, 2.1.2, 3.1, 3.2 and 5.2.6; 2) replace Section 2.1.1 with new language pertaining to Federally Funded Research and Development Centers (FFRDCs) and Government Entities. Additionally, Section 4.2, Evaluation Criteria #2 is updated to remove the reference to Government Entities (removal is not highlighted in yellow); 3) change references from Abstract to Solution Summaries (intent behind the document is unchanged); 4) update proposal submission instructions in Section 3.2; and 5) update Section 5.1 to remove the Stage 2 Notification Letter. All changes are highlighted in yellow. Also, please note that the title of this opportunity has bee revised to eliminate confusion. The opportunity should have been titled, "Master Announcement Instruction (MAI)" instead of "ARPA-H BDF Tool Box". The Master Announcement Instructions (MAI) is a new ARPA-H announcement that aims to create standard tiered proposal submission requirements, so the amount of work required to write a proposal is commensurate with the size of the proposed effort. It also aims to reduce the up-front work required to submit cost information to reduce the barrier to entry for non-traditional performers. Module announcements that link to this MAI will provide more specific instructions about how the proposal requirements vary across tiers of effort. All responsible sources capable of satisfying the Government’s needs may submit a proposal to a Module Announcement. Specifically, universities, non-profit organizations, small businesses and other than small businesses are eligible and encouraged to propose to Module Announcements. NOTE: Proposals shall NOT be submitted against the MAI. Proposals shall only be submitted against a Module Announcement.

Category: Health, Science and Technology and other Research and Development.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before

From fiscal 2021 to 2025, ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) (93.384) awarded $524 million across 42 grant awards, an average of $12.5 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of California, San FranciscoCalifornia3$51.9 million
Vanderbilt University Medical CenterTennessee2$39.8 million
University of WashingtonWashington2$38.9 million
William Marsh Rice UniversityTexas2$35.4 million
Emory UniversityGeorgia2$33.7 million

Top states: California ($135 million), Texas ($62.0 million), Massachusetts ($48.9 million), Tennessee ($45.9 million), Washington ($38.9 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is ARPA-H-MAI-24-01 still open?

No. It closed on December 31, 2024.

Who can apply for Master Announcement Instructions (MAI)?

Advanced Research Projects Agency for Health accepted applications from the applicants described in the notice. The notice adds further conditions, so read its eligibility section.

What is the deadline for Master Announcement Instructions (MAI)?

Closed December 31, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has won ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H) grants before?

The largest recipients over five fiscal years were The Regents of the University of California, San Francisco, Vanderbilt University Medical Center, University of Washington. The program made 42 awards worth $524 million in that time.

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