Well Told Grants

Grants / National Science Foundation / U.S. National Science Foundation

NSF 22-504: Macrosystems Biology and NEON-Enabled Science

Closed Closed Opportunity NSF 22-504

This grant is closed. A newer notice from the same program is open now: Major Research Instrumentation Program: (MRI) (NSF 27-500). Status: Closes January 29, 2027 (83 days left). It is in our archive of U.S. National Science Foundation notices from 2025.

U.S. National Science Foundation offered grants to the applicants described in the notice. It expected to make about 25 awards worth $12.0 million in total. It is no longer open on Grants.gov.

From the official notice on Grants.gov, last changed June 7, 2025. Checked November 7, 2026.

Key dates

PostedJune 6, 2025
Archived by Grants.govJune 7, 2025

Who can apply

This opportunity was open to the applicants described in the notice.

*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs): Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of sub-awards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus. *Who May Serve as PI: There are no restrictions or limits for either MRA orMSA proposals.

Is this a realistic fit?

What the grant funds

TheMacrosystems Biology and NEON-Enabled Science (MSB-NES): Research on Biological Systems at Regional to Continental Scalesprogram will support quantitative, interdisciplinary, systems-oriented research on biosphere processes and their complex interactions with climate, land use, and changes in species distributionatregional to continental scales as well as training activities to broaden participation of researchers in Macrosystems Biology and NEON-EnabledScience. MSB-NES projects that use data and/or resources fromthe National Ecological Observatory Network(NEON) are encouraged. Substantive NEON-enabled projects rely on data and/or samples collected by NEON and/or co-locate research activities at NEON sites. Projects may develop tools that will explicitly enhance the processing, use, and/or analysis of NEON data or collections, in the context of addressing a specific research question or hypothesis. However, proposals primarily focused on tool development that can be used for a broad class of research questions or for topics that meet the needs of a community of researchers should be directed toward the Infrastructure Innovation for Biological Research (Innovation) or Infrastructure Capacity for Biological Research (Capacity) programs in the Division of Biological Infrastructure.

Category: Science and Technology and other Research and Development.

Who has won Biological Sciences grants before

From fiscal 2021 to 2025, Biological Sciences (47.074) awarded $4.2 billion across 6,885 grant awards, an average of $609,810 per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Battelle Memorial InstituteOhio8$381 million
Arizona State UniversityArizona57$108 million
Cornell UniversityNew York85$85.6 million
University of FloridaFlorida100$70.6 million
Michigan State University FoundationMichigan105$67.9 million

Top states: California ($471 million), Ohio ($463 million), New York ($288 million), Massachusetts ($180 million), Texas ($176 million).

Applying now

This notice no longer takes applications. Apply under the newer notice, NSF 27-500, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is NSF 22-504 still open?

No. It is no longer open on Grants.gov. A newer notice is open: NSF 27-500, closes January 29, 2027 (83 days left).

Who can apply for Macrosystems Biology and NEON-Enabled Science?

U.S. National Science Foundation accepted applications from the applicants described in the notice. The notice adds further conditions, so read its eligibility section.

What is the deadline for Macrosystems Biology and NEON-Enabled Science?

Closed. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

About $12.0 million in total across about 25 awards.

Who has won Biological Sciences grants before?

The largest recipients over five fiscal years were Battelle Memorial Institute, Arizona State University, Cornell University. The program made 6,885 awards worth $4.2 billion in that time.

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