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NSF 21-501: Infrastructure Capacity for Biological Research

Closed Closed Opportunity NSF 21-501

This grant is closed. A newer notice from the same program is open now: Major Research Instrumentation Program: (MRI) (NSF 27-500). Status: Closes January 29, 2027 (83 days left). It is in our archive of U.S. National Science Foundation notices from 2025.

U.S. National Science Foundation offered grants of up to $1.2 million (at least $25,000) to the applicants described in the notice. It expected to make about 75 awards worth $20.0 million in total. It is no longer open on Grants.gov.

From the official notice on Grants.gov, last changed June 7, 2025. Checked November 7, 2026.

Other notices with this title

U.S. National Science Foundation has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
NSF 18-594June 6, 2025ClosedClosed

Key dates

PostedJune 6, 2025
Archived by Grants.govJune 7, 2025

Who can apply

This opportunity was open to the applicants described in the notice.

*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs): Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of sub-awards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.

Is this a realistic fit?

What the grant funds

The Infrastructure Capacity for Biological Research (Capacity) Program supports the implementation of, scaling of, or major improvements to research tools, products, and services that advance contemporary biology in any research area supported by the Directorate forBiological Sciences at NSF. The Capacity Program focuses on building capacity in research infrastructure that is broadly applicable to a wide range of researchers in three programmatic areas: Cyberinfrastructure, Biological Collections, and Biological Field Stations and Marine Laboratories. This program will also accept proposals for planning activities or workshops to facilitate coordination that may be necessary in building capacity in infrastructure that meets the needs of a research community. Areas not included in this program are instrumentation (PIs should submit to the MRI program) and, projects that develop infrastructure for a specific research project, laboratory, or institution (PIs should submitted to the relevant BIO programs that would normally support that research). Projects are expected to produce quality products, result in important science outcomes that will be achieved by the users of the resource, be openly accessible to a broad scientific and education community, and serve a community of researchers beyond a single research team.

Category: Science and Technology and other Research and Development.

Who has won Biological Sciences grants before

From fiscal 2021 to 2025, Biological Sciences (47.074) awarded $4.2 billion across 6,885 grant awards, an average of $609,810 per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Battelle Memorial InstituteOhio8$381 million
Arizona State UniversityArizona57$108 million
Cornell UniversityNew York85$85.6 million
University of FloridaFlorida100$70.6 million
Michigan State University FoundationMichigan105$67.9 million

Top states: California ($471 million), Ohio ($463 million), New York ($288 million), Massachusetts ($180 million), Texas ($176 million).

Applying now

This notice no longer takes applications. Apply under the newer notice, NSF 27-500, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is NSF 21-501 still open?

No. It is no longer open on Grants.gov. A newer notice is open: NSF 27-500, closes January 29, 2027 (83 days left).

Who can apply for Infrastructure Capacity for Biological Research?

U.S. National Science Foundation accepted applications from the applicants described in the notice. The notice adds further conditions, so read its eligibility section.

What is the deadline for Infrastructure Capacity for Biological Research?

Closed. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $1.2 million each. About $20.0 million in total across about 75 awards.

Who has won Biological Sciences grants before?

The largest recipients over five fiscal years were Battelle Memorial Institute, Arizona State University, Cornell University. The program made 6,885 awards worth $4.2 billion in that time.

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