| 1 | Social Services South Dakota Department · Pierre | State and local governments | 230 | $6.0 billion |
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| 2 | State of South Dakota · Pierre | State and local governments | 2,233 | $2.7 billion |
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| 3 | South Dakota Department of Education · Pierre | State and local governments | 174 | $1.7 billion |
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| 4 | South Dakota Department of Health · Pierre | State and local governments | 145 | $393 million |
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| 5 | The South Dakota Department of Agriculture and Natural Resources · Pierre | State and local governments | 138 | $311 million |
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| 6 | South Dakota Department of Public Safety · Pierre | State and local governments | 159 | $301 million |
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| 7 | South Dakota State University · Brookings | Colleges and universities | 296 | $283 million |
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| 8 | Rosebud Sioux Tribe · Rosebud | Tribal governments and organizations | 231 | $262 million |
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| 9 | Lewis & Clark Regional Water System · Tea | Nonprofits | 3 | $256 million |
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| 10 | Governors Office of Econ Dev · Pierre | State and local governments | 16 | $248 million |
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| 11 | Oglala Sioux Tribe of Pine Ridge Indian Reservation · Pine Ridge | Tribal governments and organizations | 160 | $204 million |
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| 12 | South Dakota Science & Technology Authority · Lead | State and local governments | 3 | $167 million |
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| 13 | Oglala Lakota College · Kyle | Tribal governments and organizations | 44 | $165 million |
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| 14 | State of South Dakota Department of Transportation · Pierre | State and local governments | 64 | $157 million |
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| 15 | The University of South Dakota · Vermillion | Colleges and universities | 141 | $143 million |
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| 16 | State South Dakota Game Fish & PK · Pierre | State and local governments | 264 | $138 million |
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| 17 | Department of Human Services South Dakota · Pierre | State and local governments | 115 | $125 million |
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| 18 | Department of Military Affairs · Rapid City | State and local governments | 58 | $122 million |
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| 19 | South Dakota Department of Labor & Regulation · Pierre | State and local governments | 94 | $120 million |
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| 20 | Oglala Lakota Housing Authority · Pine Ridge | Tribal governments and organizations | 14 | $95.6 million |
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| 21 | City of Rapid City · Rapid City | State and local governments | 49 | $84.3 million |
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| 22 | Oglala Lakota County School District · Batesland | State and local governments | 11 | $81.5 million |
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| 23 | Todd County School District 66-1 · Mission | State and local governments | 11 | $77.9 million |
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| 24 | Sinte Gleska University · Mission | Colleges and universities | 31 | $71.9 million |
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| 25 | Great Plains Tribal Leaders Health Board · Rapid City | Tribal governments and organizations | 56 | $68.4 million |
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| 26 | Sioux Falls Regional Airport Authority · Sioux Falls | State and local governments | 14 | $67.7 million |
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| 27 | South Dakota School of Mines & Technology · Rapid City | Colleges and universities | 131 | $65.9 million |
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| 28 | Sicangu Wicoti Awayankape Corporation · Rosebud | Tribal governments and organizations | 11 | $61.8 million |
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| 29 | Cheyenne River Sioux Tribe · Eagle Butte | Tribal governments and organizations | 133 | $61.5 million |
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| 30 | City of Sioux Falls · Sioux Falls | State and local governments | 25 | $58.5 million |
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| 31 | Horizon Health Care, Inc · Howard | Other | 10 | $58.5 million |
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| 32 | Sisseton Wahpeton Oyate · Sisseton | Tribal governments and organizations | 116 | $51.3 million |
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| 33 | Poet Holding Company, LLC · Sioux Falls | Colleges and universities | 6 | $50.9 million |
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| 34 | South Dakota Housing Development Authority · Pierre | State and local governments | 44 | $50.0 million |
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| 35 | Youth and Family Services, Inc · Rapid City | Nonprofits | 14 | $49.0 million |
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| 36 | Avera McKennan · Sioux Falls | Nonprofits | 16 | $48.5 million |
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| 37 | Cheyenne River Housing Authority · Eagle Butte | Tribal governments and organizations | 6 | $44.1 million |
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| 38 | Sisseton Wahpeton College · Sisseton | State and local governments | 32 | $39.4 million |
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| 39 | Sisseton-Wahpeton Housing Authority · Sisseton | Tribal governments and organizations | 6 | $36.8 million |
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| 40 | Four Bands Community Fund, Incorporated · Eagle Butte | Nonprofits | 10 | $36.1 million |
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| 41 | South Dakota Department of Military and Veterans Affairs · Pierre | State and local governments | 7 | $35.7 million |
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| 42 | Lower Brule Sioux Tribe · Lower Brule | Tribal governments and organizations | 79 | $35.6 million |
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| 43 | Millborn Seeds Inc · Brookings | Businesses | 1 | $35.0 million |
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| 44 | Yankton Sioux Tribe · Wagner | Tribal governments and organizations | 98 | $34.9 million |
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| 45 | Flandreau Santee Sioux Tribe · Flandreau | Tribal governments and organizations | 57 | $34.8 million |
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| 46 | Wagner Community School D · Wagner | State and local governments | 11 | $33.7 million |
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| 47 | City of Watertown · Watertown | State and local governments | 14 | $33.7 million |
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| 48 | Rural America Initiatives · Rapid City | Tribal governments and organizations | 7 | $33.6 million |
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| 49 | Oglala Sioux Tribe of Pine Ridge Indian Reservation · Pine Ridge | Tribal governments and organizations | 10 | $33.0 million |
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| 50 | Inter-Lakes Community Action Partnership, Inc. · Madison | Nonprofits | 20 | $32.3 million |
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| 51 | Douglas School District 51-1 · Box Elder | State and local governments | 14 | $32.1 million |
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| 52 | South Dakota Ellsworth Development Authority · Rapid City | State and local governments | 1 | $30.0 million |
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| 53 | Crow Creek Sioux Tribe · Fort Thompson | Tribal governments and organizations | 9 | $25.7 million |
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| 54 | White River School District 47-1 · White River | State and local governments | 12 | $24.9 million |
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| 55 | Black Hills State University · Spearfish | Colleges and universities | 19 | $24.7 million |
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| 56 | City of Aberdeen · Aberdeen | State and local governments | 20 | $24.3 million |
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| 57 | Little Wound School Board, Inc · Kyle | Tribal governments and organizations | 17 | $24.3 million |
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| 58 | SD Air National Guard · Sioux Falls | State and local governments | 17 | $23.8 million |
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| 59 | Sisseton School District 54-2 · Sisseton | State and local governments | 11 | $22.0 million |
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| 60 | Eagle Butte School District 20-1 · Eagle Butte | State and local governments | 11 | $21.3 million |
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| 61 | Black Hills Electric Cooperative, Inc. · Custer | Other | 1 | $20.5 million |
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| 62 | Attorney General's Office of South Dakota · Pierre | State and local governments | 37 | $20.0 million |
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| 63 | CRST Telephone Authority · Eagle Butte | Tribal governments and organizations | 2 | $19.3 million |
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| 64 | Rural Health Care, Inc. · Fort Pierre | Other | 4 | $19.2 million |
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| 65 | Sioux Falls School District No 49-5 · Sioux Falls | State and local governments | 8 | $18.8 million |
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| 66 | Community Health Center of the Black Hills, Inc. · Rapid City | Other | 6 | $18.4 million |
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| 67 | Bennett County School District 3-1 · Martin | State and local governments | 6 | $18.3 million |
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| 68 | City of Pierre · Pierre | State and local governments | 10 | $18.1 million |
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| 69 | Glacial Lakes Corn Processors · Watertown | Other | 2 | $18.0 million |
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| 70 | South Central Child Development, Inc. · Wagner | Nonprofits | 3 | $17.9 million |
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| 71 | McLaughlin School District 15 2 · Mc Laughlin | State and local governments | 10 | $17.3 million |
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| 72 | South Dakota Department of Public Safety · Rapid City | State and local governments | 24 | $16.8 million |
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| 73 | Northeast SD Headstart Program Inc · Aberdeen | Nonprofits | 3 | $16.6 million |
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| 74 | Yankton Sioux Housing Authority · Wagner | Tribal governments and organizations | 3 | $15.4 million |
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| 75 | Community Healthcare Association of the Dakotas · Sioux Falls | Nonprofits | 9 | $15.3 million |
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| 76 | Dakota State University · Madison | Colleges and universities | 15 | $15.1 million |
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| 77 | Oahe Child Development Center, Inc. · Pierre | Nonprofits | 3 | $14.9 million |
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| 78 | Timber Lake School District 20-3 · Timber Lake | State and local governments | 11 | $14.8 million |
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| 79 | Southeast Technical Institute · Sioux Falls | State and local governments | 3 | $14.4 million |
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| 80 | The Lakota Fund, Inc. · Kyle | Nonprofits | 6 | $14.2 million |
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| 81 | Lutheran Social Services of South Dakota · Sioux Falls | Nonprofits | 20 | $13.9 million |
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| 82 | Pennington County Housing and Redevelopment Commission · Rapid City | State and local governments | 17 | $13.9 million |
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| 83 | Andes Central School District · Lake Andes | State and local governments | 16 | $13.6 million |
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| 84 | Grow South Dakota · Sisseton | Nonprofits | 9 | $13.4 million |
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| 85 | Lower Brule Housing Authority · Lower Brule | Tribal governments and organizations | 5 | $13.4 million |
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| 86 | Dupree School District 64-2 · Dupree | State and local governments | 11 | $12.6 million |
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| 87 | Web Water Development Association, Inc. · Aberdeen | Nonprofits | 2 | $12.4 million |
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| 88 | State of South Dakota-Division of Oasi · Pierre | Businesses | 3 | $12.4 million |
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| 89 | VRC Metal Systems, LLC · Box Elder | Small businesses | 5 | $11.7 million |
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| 90 | Mni Waste' Water Company · Eagle Butte | Nonprofits | 5 | $11.1 million |
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| 91 | Ellis & Eastern Company · Sioux Falls | Businesses | 1 | $10.6 million |
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| 92 | Lake Area Technical College · Watertown | Colleges and universities | 5 | $10.5 million |
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| 93 | Technology for Rural Enhancement of Communities · Belle Fourche | Nonprofits | 2 | $10.1 million |
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| 94 | South Dakota Network Against Family Violence and Sexual Assault, Inc · Sioux Falls | Nonprofits | 23 | $9.9 million |
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| 95 | Oelrichs School District · Oelrichs | State and local governments | 21 | $9.6 million |
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| 96 | Northern State University · Aberdeen | Colleges and universities | 10 | $9.2 million |
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| 97 | Wakpala School District 15-3 · Wakpala | State and local governments | 11 | $8.9 million |
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| 98 | Mitchell School District 17-2 · Mitchell | Colleges and universities | 4 | $8.9 million |
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| 99 | Crow Creek Sioux Tribe · Fort Thompson | Tribal governments and organizations | 40 | $8.8 million |
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| 100 | State of South Dakota · Pierre | State and local governments | 7 | $8.6 million |
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