# Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847)

Source: https://welltoldgrants.com/programs/93-847-diabetes-digestive-and-kidney-diseases-extramural-research/  
Publisher: Well Told Grants. Data: USAspending.gov and Grants.gov, updated November 7, 2026.

Diabetes, Digestive, and Kidney Diseases Extramural Research is run by Department of Health and Human Services. From fiscal 2021 to 2025 it awarded $9.6 billion in 7,877 grants, about $1.2 million per award.

## Objectives

(1) To promote extramural basic and clinical biomedical research that improves the understanding of the mechanisms underlying disease and leads to improved preventions, diagnosis, and treatment of diabetes, digestive, and kidney diseases. Programmatic areas within the National Institute of Diabetes and Digestive and Kidney Diseases include diabetes, digestive, endocrine, hematologic, liver, metabolic, nephrologic, nutrition, obesity, and urologic diseases. Specific programs areas of interest include the following: (a) For diabetes, endocrine, and metabolic diseases areas: Fundamental and clinical studies including the etiology, pathogenesis, prevention, diagnosis, treatment and cure of diabetes mellitus and its complications; Normal and abnormal function of the pituitary, thyroid, parathyroid, adrenal, and other hormone secreting glands; Hormonal regulation of bone, adipose tissue, and liver; on fundamental aspects of signal transduction, including the action of hormones, coregulators, and chromatin remodeling proteins; Hormone biosynthesis, secretion, metabolism, and binding; and on hormonal regulation of gene expression and the role(s) of selective receptor modulators as partial agonists or antagonists of hormone action; and Fundamental studies relevant to metabolic disorders including membrane structure, function, and transport phenomena and enzyme biosynthesis; and basic and clinical studies on the etiology, pathogenesis, prevention, and treatment of inherited metabolic disorders (such as cystic fibrosis). (b) For digestive disease and nutrition areas: Genetics and genomics of the GI tract and its diseases; Genetics and genomics of liver/pancreas and diseases; Genetics and genomics of nutrition; genetics and genomics of obesity; Bariatric surgery; Clinical nutrition research; Clinical obesity research; Complications of chronic liver disease; Fatty liver disease; Genetic liver disease; HIV and liver; Cell injury, repair, fibrosis and inflammation in the liver; Liver cancer; Liver transplantation; Pediatric liver disease; Viral hepatitis and infectious diseases; Gastrointestinal and nutrition effects of AIDS; Gastrointestinal mucosal and immunology; Gastrointestinal motility; Basic neurogastroenterology; Gastrointestinal development; Gastrointestinal epithelial biology; Gastrointestinal inflammation; Digestive diseases epidemiology and data systems; Nutritional epidemiology and data systems; Autoimmune liver disease; Bile, Bilirubin and cholestasis; Bioengineering and biotechnology related to digestive diseases, liver, nutrition and obesity; Cell and molecular biology of the liver; Developmental biology and regeneration; Drug-induced liver disease; Gallbladder disease and biliary diseases; Exocrine pancreas biology and diseases; Gastrointestinal neuroendocrinology; Gastrointestinal transport and absorption; Nutrient metabolism; Pediatric clinical obesity; Clinical trials in digestive diseases; Liver clinical trials; Obesity prevention and treatment; and Obesity and eating disorders. (c) For kidney, urologic and hematologic diseases areas: Studies of the development, physiology, and cell biology of the kidney; Pathophysiology of the kidney; Genetics of kidney disorders; Immune mechanisms of kidney disease; Kidney disease as a complication of diabetes; Effects of drugs, nephrotoxins and environmental toxins on the kidney; Mechanisms of kidney injury repair; Improved diagnosis, prevention and treatment of chronic kidney disease and end-stage renal disease; Improved approaches to maintenance dialysis therapies; Basic studies of lower urinary tract cell biology, development, physiology, and pathophysiology; Clinical studies of bladder dysfunction, incontinence, pyelonephritis, interstitial cystitis, benign prostatic hyperplasia, urolithiasis, and vesicoureteral reflux; Development of novel diagnostic tools and improved therapies, including tissue engineering strategies, for urologic disorders;Research on hematopoietic cell differentiation; metabolism of iron overload and deficiency; Structure, biosynthesis and genetic regulation of hemoglobin; as well as Research on the etiology, pathogenesis, and therapeutic modalities for the anemia of inflammation and chronic diseases.
(2) To encourage basic and clinical research training and career development of scientists during the early stages of their careers. The Ruth L. Kirschstein National Research Service Award (NRSA) funds basic and clinical research training, support for career development, and the transition from postdoctoral biomedical research training to independent research related to diabetes, digestive, endocrine, hematologic, liver, metabolic, nephrologic, nutrition, obesity, and urologic diseases. (3) To expand and improve the Small Business Innovation Research (SBIR) program. The SBIR Program aims to increase and facilitate private sector commercialization of innovations derived from Federal research and development; to enhance small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. (4) To utilize the Small Business Technology Transfer (STTR) program. The STTR Program intends to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.

## Funding by fiscal year

| Year | Amount | Awards |
|---|---|---|
| 2021 | $1.8 billion | 4,162 |
| 2022 | $1.9 billion | 4,234 |
| 2023 | $2.0 billion | 4,281 |
| 2024 | $1.9 billion | 4,236 |
| 2025 | $2.0 billion | 3,835 |

## Largest recipients

| Recipient | State | Amount |
|---|---|---|
| Regents of the University of Michigan | Michigan | $345 million |
| The Trustees of the University of Pennsylvania | Pennsylvania | $272 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | $238 million |
| The Washington University | Missouri | $227 million |
| The Regents of the University of California, San Francisco | California | $208 million |
| Yale Univ | Connecticut | $207 million |
| University of South Florida | Florida | $205 million |
| The Regents of the University of Colorado | Colorado | $204 million |
| Vanderbilt University Medical Center | Tennessee | $200 million |
| The Trustees of Columbia University in the City of New York | New York | $193 million |
| Icahn School of Medicine at Mount Sinai | New York | $192 million |
| University of California, San Diego | California | $190 million |
| The General Hospital Corporation | Massachusetts | $186 million |
| The Leland Stanford Junior University | California | $171 million |
| Mayo Clinic Jacksonville (a Nonprofit Corporation) | Minnesota | $169 million |
| The Johns Hopkins University | Maryland | $160 million |
| The University of Texas Southwestern Medical Center | Texas | $152 million |
| University of North Carolina at Chapel Hill | North Carolina | $152 million |
| Baylor College of Medicine | Texas | $141 million |
| Northwestern University | Illinois | $137 million |

## Open opportunities

- [Single Source for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Scientific and Data Research Center (U01 Clinical Trial Required)](https://welltoldgrants.com/grants/rfa-dk-27-139-single-source-for-the-continuation-of-the-caring/), closes November 9, 2026
- [Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-dk-27-112-single-source-for-the-continuation-of-the-epidemiology/), closes November 9, 2026
- [Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)](https://welltoldgrants.com/grants/rfa-dk-27-122-single-source-for-the-continuation-of-the-physiology/), closes November 17, 2026
- [NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/rfa-od-24-011-nih-research-software-engineer-rse-award-r50-clinical/), closes December 4, 2026
- [Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-379-intervention-research-to-improve-native-american-health-r01/), closes January 7, 2027
- [HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-25-023-heal-initiative-studies-to-enable-analgesic-discovery-r61/), closes January 15, 2027
- [Diabetes Research Centers (P30 Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-dk-26-310-diabetes-research-centers-p30-clinical-trial-optional/), closes January 27, 2027
- [Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-dk-27-119-silvio-o-conte-digestive-diseases-research-core-centers/), closes February 10, 2027
- [Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-dk-27-108-continuation-of-the-cardiovascular-repository-for-type-1/), closes March 10, 2027
- [NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-100-nih-cdc-and-fda-small-business-innovation-research/), closes April 5, 2027
- [NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-102-nih-small-business-technology-transfer-grant-parent-sttr/), closes April 5, 2027
- [Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/rfa-od-25-003-short-courses-on-innovative-methodologies-and-approaches-in/), closes April 9, 2027
- [Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-185-mentored-patient-oriented-research-career-development-award/), closes May 7, 2027
- [Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-190-mentored-quantitative-research-development-award-parent-k25/), closes May 7, 2027
- [Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-191-mentored-quantitative-research-development-award-parent-k25/), closes May 7, 2027
- [Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-175-mentored-research-scientist-development-award-parent-k01/), closes May 7, 2027
- [Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-176-mentored-research-scientist-development-award-parent-k01/), closes May 7, 2027
- [NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-194-nih-pathway-to-independence-award-parent-k99-r00/), closes May 7, 2027
- [NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-193-nih-pathway-to-independence-award-parent-k99-r00/), closes May 7, 2027
- [Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-184-mentored-patient-oriented-research-career-development-award/), closes May 8, 2027
- [Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-182-mentored-clinical-scientist-research-career-development/), closes May 8, 2027
- [Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-254-change-of-recipient-organization-type-7-parent-clinical/), closes July 12, 2027
- [Successor-in-Interest (Type 6 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-253-successor-in-interest-type-6-parent-clinical-trial/), closes July 17, 2027
- [Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)](https://welltoldgrants.com/grants/pas-25-073-priority-hiv-aids-research-within-the-mission-of/), closes November 5, 2027
- [Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-068-pilot-studies-of-biological-behavioral-and-social-mechanisms/), closes November 16, 2027
- [Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pas-25-205-stimulating-hematology-investigation-new-endeavors-shine/), closes January 6, 2028
- [Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-144-dissemination-and-implementation-research-in-health-r01/), closes January 7, 2028
- [Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-134-academic-research-enhancement-award-area-for-undergraduate/), closes January 7, 2028
- [NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-301-nih-research-project-grant-parent-r01-clinical-trial/), closes January 7, 2028
- [NIH Research Project Grant (Parent R01 Clinical Trial Required)](https://welltoldgrants.com/grants/pa-25-305-nih-research-project-grant-parent-r01-clinical-trial/), closes January 7, 2028
- [Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-091-limited-competition-small-grant-program-for-niddk-k01/), closes January 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)](https://welltoldgrants.com/grants/pa-25-168-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 4, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)](https://welltoldgrants.com/grants/pa-25-280-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)](https://welltoldgrants.com/grants/pa-25-423-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)](https://welltoldgrants.com/grants/pa-25-425-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)](https://welltoldgrants.com/grants/pa-25-426-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)](https://welltoldgrants.com/grants/pa-25-422-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Institutional Network Award for Promoting Kidney, Urologic, and Hematologic Research Training (U2C - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-26-115-institutional-network-award-for-promoting-kidney-urologic/), closes May 26, 2028
- [INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-od-27-004-include-project-transformative-research-awards-for-down/), closes June 15, 2028
- [INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)](https://welltoldgrants.com/grants/rfa-od-27-005-include-project-clinical-trials-phased-awards-for-down/), closes June 15, 2028
- [Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-076-lasker-clinical-research-scholar-s-program-si2-r00/), closes July 7, 2028
- [Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-322-stephen-i-katz-early-stage-investigator-research-project/), closes August 25, 2028
- [Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-414-support-for-research-excellence-sure-award-r16-clinical/), closes September 7, 2028
- [Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-415-support-for-research-excellence-first-independent-research/), closes September 7, 2028
- [Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-001-administrative-supplements-to-existing-nih-grants-and/), closes November 30, 2028
- [SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-098-sbir-sttr-commercialization-readiness-pilot-crp-program/), closes April 5, 2029
- [NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-101-nih-small-business-innovation-research-sbir-phase-iib/), closes April 5, 2029
- [NIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-27-036-nih-research-education-program-research-experiences-parent/), closes May 5, 2029
- [NIH Research Educational Program - Mentoring Activities & Networks (Parent R25/UE5 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-27-035-nih-research-educational-program-mentoring-activities/), closes May 5, 2029
- [NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-002-nih-collaborative-international-research-project-parent-pf5/), closes May 7, 2029
- [NIH Research Education Program - Courses, Curriculum & Methods (Parent R25 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-27-034-nih-research-education-program-courses-curriculum-methods/), closes May 25, 2029
- [Centers for AIDS Research (CFAR) and Developmental Centers for AIDS Research (D-CFAR) (P30 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-28-090-centers-for-aids-research-cfar-and-developmental-centers/), closes May 25, 2029
- [Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-ai-27-018-implementation-science-to-advance-hiv-prevention-treatment/), closes June 20, 2029
- [Institutional Mentored Career Development Award (Parent K12) (Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/pa-27-030-institutional-mentored-career-development-award-parent-k12/), closes July 12, 2029
- [The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genomic Research Centers](https://welltoldgrants.com/grants/rfa-dk-27-116-the-niddk-inflammatory-bowel-disease-genetics-consortium/), closes not stated
- [The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Data Coordinating Center](https://welltoldgrants.com/grants/rfa-dk-27-124-the-niddk-inflammatory-bowel-disease-genetics-consortium/), closes not stated
- [Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-039-small-business-transition-grant-for-new-entrepreneurs-parent/), closes not stated
- [NIDDK Multi-Purpose Resource-Related, Multi-Component Research Services Centers Cooperative Agreement (U2C - Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-dk-28-114-niddk-multi-purpose-resource-related-multi-component/), closes not stated
- [KUH P30 Resource Core Center (P30 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-dk-28-312-kuh-p30-resource-core-center-p30-clinical-trial/), closes not stated
- [KUH U24 Center Coordinating Hub (U24 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-dk-28-313-kuh-u24-center-coordinating-hub-u24-clinical-trial/), closes not stated
- [Multimodal AI to Accelerate Precision Medicine for Type 1 Diabetes (U01- Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/rfa-dk-28-116-multimodal-ai-to-accelerate-precision-medicine-for-type/), closes not stated
- [Single Source Competition for Continuation of Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-dk-28-115-single-source-competition-for-continuation-of-understanding/), closes not stated
- [Implementation and Evaluation of Databases to Examine AIDS](https://welltoldgrants.com/grants/rfa-ai-28-025-implementation-and-evaluation-of-databases-to-examine-aids/), closes not stated
- [NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-dk-28-112-niddk-disease-research-and-translational-core-centers-p30/), closes not stated