# 21st Century Cures Act -	Brain Research through Advancing Innovative Neurotechnologies (93.372)

Source: https://welltoldgrants.com/programs/93-372-21st-century-cures-act-brain-research-through-advancing/  
Publisher: Well Told Grants. Data: USAspending.gov and Grants.gov, updated November 7, 2026.

21st Century Cures Act -	Brain Research through Advancing Innovative Neurotechnologies is run by Department of Health and Human Services. From fiscal 2021 to 2025 it awarded $468 million in 395 grants, about $1.2 million per award.

## Objectives

To provide extramural research support for the Brain Research Through Advancing Innovative Neurotechnologies®?(BRAIN) Initiative’s aim of revolutionizing our understanding of the brain and its function in unprecedented detail. The NIH BRAIN Initiative’s focus is foundational development of new technologies and tools to map, monitor, and modulate brain circuits in model systems and humans – toward the ultimate goal of treating and curing human brain disorders. BRAIN Initiative research adheres to open, ethical, and inclusive science – and requires diverse expertise across all domains. BRAIN-supported research areas include comprehensive cataloguing, mapping, accessing and characterization of brain cell types ; probing neural circuits that interact and produce behavior, cognition, and emotion; developing and employing new ?technologies to monitor function and connectivity of synapses, circuits, and whole brains; partnering with human research participants, including ?utilizing neurotechnologies in first-in-human clinical studies, to study the human brain in the context of brain injury and brain disorders; and establishing data-sharing platforms and computational models that help decode brain processes and functions. Within these scientific focus areas, the Initiative supports research project grants, cooperative agreements, workforce development awards and Small Business Innovation Research awards. Research supported by the Initiative has a strong commitment to broad dissemination of newly developed technologies, and to considering neuroethical issues related to studying the human brain and the neuroscience advances that follow from this research. New frontiers for BRAIN research will adhere to, and build on, what has been learned to date and adapt to the rapidly changing scientific landscape and neuroscience ecosystem.

## Funding by fiscal year

| Year | Amount | Awards |
|---|---|---|
| 2021 | $35.5 million | 110 |
| 2022 | $63.9 million | 110 |
| 2023 | $188 million | 212 |
| 2024 | $95.4 million | 161 |
| 2025 | $85.0 million | 170 |

## Largest recipients

| Recipient | State | Amount |
|---|---|---|
| The Leland Stanford Junior University | California | $24.6 million |
| Allen Institute | Washington | $21.9 million |
| President and Fellows of Harvard College | Massachusetts | $21.5 million |
| Baylor College of Medicine | Texas | $18.9 million |
| The General Hospital Corporation | Massachusetts | $17.0 million |
| The Johns Hopkins University | Maryland | $15.8 million |
| New York University | New York | $14.3 million |
| University of Texas Health Science Center at Houston | Texas | $13.2 million |
| Regents of the University of Minnesota | Minnesota | $12.9 million |
| University of California, Los Angeles | California | $12.7 million |
| The Salk Institute for Biological Studies, San Diego, California | California | $12.3 million |
| The Regents of the University of California, San Francisco | California | $12.2 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | $11.5 million |
| Massachusetts Institute of Technology | Massachusetts | $11.4 million |
| University of Washington | Washington | $11.0 million |
| The Regents of the University of California | California | $10.9 million |
| The Trustees of the University of Pennsylvania | Pennsylvania | $10.8 million |
| The Trustees of Columbia University in the City of New York | New York | $9.9 million |
| Duke University | North Carolina | $9.5 million |
| University of Southern California | California | $8.4 million |

## Open opportunities

- [BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-27-015-brain-initiative-connectivity-across-scales-brain-connects/), closes October 4, 2027
- [BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-da-27-004-brain-initiative-theories-models-and-methods-for-analysis/), closes November 8, 2027
- [BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-27-002-brain-initiative-integrative-team-research-brain-circuits/), closes June 23, 2028
- [Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-076-lasker-clinical-research-scholar-s-program-si2-r00/), closes July 7, 2028
- [BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-27-001-brain-initiative-research-resource-grants-for-technology/), closes October 6, 2028
- [Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-001-administrative-supplements-to-existing-nih-grants-and/), closes November 30, 2028
- [BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-28-010-brain-initiative-research-opportunities-using-invasive/), closes February 8, 2029
- [NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-002-nih-collaborative-international-research-project-parent-pf5/), closes May 7, 2029
- [BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative Research on Behavior at the Organismal Level](https://welltoldgrants.com/grants/rfa-da-27-011-brain-initiative-brain-behavior-quantification-and/), closes not stated
- [BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System](https://welltoldgrants.com/grants/rfa-ns-28-006-brain-initiative-clinical-studies-to-advance-next-generation/), closes not stated
- [Limited Competition: BRAIN Initiative: Promoting Health for All Through BRAIN Technology Partnerships](https://welltoldgrants.com/grants/rfa-ns-28-005-limited-competition-brain-initiative-promoting-health-for/), closes not stated