# Research Infrastructure Programs (93.351)

Source: https://welltoldgrants.com/programs/93-351-research-infrastructure-programs/  
Publisher: Well Told Grants. Data: USAspending.gov and Grants.gov, updated November 7, 2026.

Research Infrastructure Programs is run by Department of Health and Human Services. From fiscal 2021 to 2025 it awarded $1.4 billion in 1,102 grants, about $1.3 million per award.

## Objectives

The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).

## Funding by fiscal year

| Year | Amount | Awards |
|---|---|---|
| 2021 | $272 million | 321 |
| 2022 | $277 million | 385 |
| 2023 | $280 million | 367 |
| 2024 | $279 million | 354 |
| 2025 | $281 million | 325 |

## Largest recipients

| Recipient | State | Amount |
|---|---|---|
| University of California, Davis | California | $102 million |
| Oregon Health & Science University | Oregon | $92.1 million |
| University of Washington | Washington | $79.5 million |
| Emory University | Georgia | $78.3 million |
| The Administrators of Tulane Educational Fund | Louisiana | $68.0 million |
| University of Wisconsin System | Wisconsin | $63.5 million |
| Texas Biomedical Research Institute | Texas | $53.7 million |
| University of Missouri System | Missouri | $33.7 million |
| Jackson Laboratory | Maine | $33.4 million |
| The General Hospital Corporation | Massachusetts | $32.9 million |
| University of Puerto Rico Medical Sciences Campus | Puerto Rico | $29.0 million |
| Baylor College of Medicine | Texas | $28.5 million |
| The Johns Hopkins University | Maryland | $19.0 million |
| The Leland Stanford Junior University | California | $17.6 million |
| University of Alabama at Birmingham | Alabama | $17.5 million |
| University of North Carolina at Chapel Hill | North Carolina | $16.5 million |
| Regents of the University of Minnesota | Minnesota | $15.9 million |
| The Regents of the University of Colorado | Colorado | $15.3 million |
| University of Oregon | Oregon | $15.1 million |
| The Washington University | Missouri | $13.8 million |

## Open opportunities

- [NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-100-nih-cdc-and-fda-small-business-innovation-research/), closes April 5, 2027
- [NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-102-nih-small-business-technology-transfer-grant-parent-sttr/), closes April 5, 2027
- [Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-176-mentored-research-scientist-development-award-parent-k01/), closes May 7, 2027
- [Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-254-change-of-recipient-organization-type-7-parent-clinical/), closes July 12, 2027
- [Successor-in-Interest (Type 6 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-253-successor-in-interest-type-6-parent-clinical-trial/), closes July 17, 2027
- [Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-185-screening-and-functional-validation-of-genomic-variants/), closes January 7, 2028
- [Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-273-development-of-animal-models-and-related-biological/), closes January 7, 2028
- [Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-298-research-enhancement-award-program-reap-for-health/), closes January 7, 2028
- [NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-301-nih-research-project-grant-parent-r01-clinical-trial/), closes January 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)](https://welltoldgrants.com/grants/pa-25-168-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 4, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)](https://welltoldgrants.com/grants/pa-25-280-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-od-27-003-include-project-exploratory-developmental-research-awards/), closes June 15, 2028
- [INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-od-27-004-include-project-transformative-research-awards-for-down/), closes June 15, 2028
- [Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-022-shared-instrumentation-grant-sig-program-s10-clinical-trial/), closes July 1, 2028
- [Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-021-seed-instrumentation-support-sis-program-s10-clinical-trial/), closes July 1, 2028
- [Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-322-stephen-i-katz-early-stage-investigator-research-project/), closes August 25, 2028
- [Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-od-25-011-animal-and-biological-material-resource-centers-p40-clinical/), closes September 26, 2028
- [Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/rfa-od-25-010-resource-related-research-projects-for-development-of-models/), closes September 28, 2028
- [Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-001-administrative-supplements-to-existing-nih-grants-and/), closes November 30, 2028
- [Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-067-limited-competition-instrumentation-grant-program-for/), closes January 26, 2029
- [SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-098-sbir-sttr-commercialization-readiness-pilot-crp-program/), closes April 5, 2029
- [NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-101-nih-small-business-innovation-research-sbir-phase-iib/), closes April 5, 2029
- [NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-002-nih-collaborative-international-research-project-parent-pf5/), closes May 7, 2029
- [Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-029-research-resource-for-a-national-swine-resource-and/), closes not stated
- [National Biomedical Research Centers (P50 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-28-017-national-biomedical-research-centers-p50-clinical-trial/), closes not stated
- [Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-28-019-integrated-specific-pathogen-free-research-models-and-human/), closes not stated
- [Small Instruments and Modern Equipment for Shared-use Biomedical Research Facilities and Resources (S15 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-28-060-small-instruments-and-modern-equipment-for-shared-use/), closes not stated
- [Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications (U42 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-28-084-testing-centers-for-evaluation-of-somatic-cell-genome/), closes not stated
- [Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-29-002-development-of-models-new-approach-methodologies-and/), closes not stated