# Discovery and Applied Research for Technological Innovations to Improve Human Health (93.286)

Source: https://welltoldgrants.com/programs/93-286-discovery-and-applied-research-for-technological/  
Publisher: Well Told Grants. Data: USAspending.gov and Grants.gov, updated November 7, 2026.

Discovery and Applied Research for Technological Innovations to Improve Human Health is run by Department of Health and Human Services. From fiscal 2021 to 2025 it awarded $1.8 billion in 1,983 grants, about $886,380 per award.

## Objectives

To support hypothesis-, design-, technology-, or device-driven research related to the discovery, design, development, validation, and application of technologies for biomedical imaging and bioengineering. The program includes biomaterials (biomimetics, bioprocessing, organogenesis, rehabilitation, tissue engineering, implant science, material science, interface science, physics and stress engineering, technology assessment of materials/devices), biosensors/biotransducers (technology development, technology assessment, development of algorithms, telemetry), nanotechnology (nanoscience, biomimetics, drug delivery systems, drug bioavailability, microarray/combinatorial technology, genetic engineering, computer science, technology assessment), bioinformatics (computer science, information science, mathematics, biomechanics, computational modeling and simulation, remote diagnosis and therapy), imaging device development, biomedical imaging technology development, image exploitation, contrast agents, informatics and computer sciences related to imaging, molecular and cellular imaging, bioelectrics/biomagnetics, organ and whole body imaging, screening for diseases and disorders, and imaging technology assessment and surgery (technique development and technology development).

## Funding by fiscal year

| Year | Amount | Awards |
|---|---|---|
| 2021 | $356 million | 884 |
| 2022 | $358 million | 922 |
| 2023 | $360 million | 918 |
| 2024 | $344 million | 850 |
| 2025 | $340 million | 789 |

## Largest recipients

| Recipient | State | Amount |
|---|---|---|
| The General Hospital Corporation | Massachusetts | $83.5 million |
| The Johns Hopkins University | Maryland | $83.5 million |
| The Leland Stanford Junior University | California | $53.0 million |
| Brigham & Womens Hospital Inc | Massachusetts | $49.5 million |
| The Trustees of the University of Pennsylvania | Pennsylvania | $48.3 million |
| University of California, Davis | California | $39.8 million |
| The Washington University | Missouri | $38.4 million |
| Massachusetts Institute of Technology | Massachusetts | $37.2 million |
| Regents of the University of Michigan | Michigan | $31.2 million |
| The Regents of the University of California, San Francisco | California | $31.0 million |
| Yale Univ | Connecticut | $31.0 million |
| Duke University | North Carolina | $30.5 million |
| Trustees of Boston University | Massachusetts | $30.1 million |
| University of Wisconsin System | Wisconsin | $29.5 million |
| University of Illinois | Illinois | $29.4 million |
| University of California, Los Angeles | California | $28.9 million |
| University of Washington | Washington | $27.2 million |
| Regents of the University of Minnesota | Minnesota | $26.5 million |
| New York University | New York | $25.4 million |
| Case Western Reserve University | Ohio | $23.0 million |

## Open opportunities

- [NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/rfa-od-24-011-nih-research-software-engineer-rse-award-r50-clinical/), closes December 4, 2026
- [Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-379-intervention-research-to-improve-native-american-health-r01/), closes January 7, 2027
- [BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-24-031-brain-initiative-preclinical-proof-of-concept-for-novel/), closes January 28, 2027
- [BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-mh-26-170-brain-initiative-development-and-validation-of-novel-tools/), closes February 8, 2027
- [BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-dc-27-004-brain-initiative-exploratory-research-opportunities-using/), closes February 11, 2027
- [NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-100-nih-cdc-and-fda-small-business-innovation-research/), closes April 5, 2027
- [NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-102-nih-small-business-technology-transfer-grant-parent-sttr/), closes April 5, 2027
- [Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-185-mentored-patient-oriented-research-career-development-award/), closes May 7, 2027
- [Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-190-mentored-quantitative-research-development-award-parent-k25/), closes May 7, 2027
- [Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-191-mentored-quantitative-research-development-award-parent-k25/), closes May 7, 2027
- [Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-175-mentored-research-scientist-development-award-parent-k01/), closes May 7, 2027
- [Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-176-mentored-research-scientist-development-award-parent-k01/), closes May 7, 2027
- [NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-194-nih-pathway-to-independence-award-parent-k99-r00/), closes May 7, 2027
- [NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-193-nih-pathway-to-independence-award-parent-k99-r00/), closes May 7, 2027
- [New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-279-new-approaches-for-measuring-brain-changes-across-longer/), closes May 7, 2027
- [Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-184-mentored-patient-oriented-research-career-development-award/), closes May 8, 2027
- [Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-181-mentored-clinical-scientist-research-career-development/), closes May 8, 2027
- [Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-182-mentored-clinical-scientist-research-career-development/), closes May 8, 2027
- [BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-mh-26-120-brain-initiative-reagent-resources-for-brain-cell-type/), closes June 15, 2027
- [BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-mh-26-140-brain-initiative-brain-behavior-quantification-and/), closes June 15, 2027
- [Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-254-change-of-recipient-organization-type-7-parent-clinical/), closes July 12, 2027
- [Successor-in-Interest (Type 6 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-253-successor-in-interest-type-6-parent-clinical-trial/), closes July 17, 2027
- [NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-080-nih-support-for-conferences-and-scientific-meetings-parent/), closes September 7, 2027
- [Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-24-325-bioengineering-partnerships-with-industry-u01-clinical/), closes September 7, 2027
- [BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-27-015-brain-initiative-connectivity-across-scales-brain-connects/), closes October 4, 2027
- [BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-da-27-004-brain-initiative-theories-models-and-methods-for-analysis/), closes November 8, 2027
- [Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-134-academic-research-enhancement-award-area-for-undergraduate/), closes January 7, 2028
- [Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-298-research-enhancement-award-program-reap-for-health/), closes January 7, 2028
- [NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-302-nih-small-research-grant-program-parent-r03-clinical/), closes January 7, 2028
- [NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-304-nih-exploratory-developmental-research-project-grant-parent/), closes January 7, 2028
- [NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)](https://welltoldgrants.com/grants/pa-25-306-nih-exploratory-developmental-research-project-grant-parent/), closes January 7, 2028
- [NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-301-nih-research-project-grant-parent-r01-clinical-trial/), closes January 7, 2028
- [NIH Research Project Grant (Parent R01 Clinical Trial Required)](https://welltoldgrants.com/grants/pa-25-305-nih-research-project-grant-parent-r01-clinical-trial/), closes January 7, 2028
- [Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-383-blueprint-medtech-translator-ug3-uh3-clinical-trial-optional/), closes January 28, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)](https://welltoldgrants.com/grants/pa-25-168-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 4, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)](https://welltoldgrants.com/grants/pa-25-280-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)](https://welltoldgrants.com/grants/pa-25-423-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)](https://welltoldgrants.com/grants/pa-25-425-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)](https://welltoldgrants.com/grants/pa-25-422-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-27-002-brain-initiative-integrative-team-research-brain-circuits/), closes June 23, 2028
- [Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)](https://welltoldgrants.com/grants/rfa-dc-27-003-transformative-non-invasive-minimally-invasive-technologies/), closes August 21, 2028
- [Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-322-stephen-i-katz-early-stage-investigator-research-project/), closes August 25, 2028
- [Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-414-support-for-research-excellence-sure-award-r16-clinical/), closes September 7, 2028
- [Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-415-support-for-research-excellence-first-independent-research/), closes September 7, 2028
- [Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-001-administrative-supplements-to-existing-nih-grants-and/), closes November 30, 2028
- [Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-067-limited-competition-instrumentation-grant-program-for/), closes January 26, 2029
- [BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-28-010-brain-initiative-research-opportunities-using-invasive/), closes February 8, 2029
- [SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-098-sbir-sttr-commercialization-readiness-pilot-crp-program/), closes April 5, 2029
- [Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-27-037-predoctoral-to-postdoctoral-transition-award-parent-f99-k00/), closes April 8, 2029
- [NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-002-nih-collaborative-international-research-project-parent-pf5/), closes May 7, 2029
- [NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-077-nih-science-education-partnership-award-sepa-r25-clinical/), closes May 25, 2029
- [Academic Career Excellence (ACE) Award (K32 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-062-academic-career-excellence-ace-award-k32-independent/), closes July 12, 2029
- [NextTech: Translational Development of Next-Generation Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-eb-28-004-nexttech-translational-development-of-next-generation/), closes December 1, 2030
- [National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional)](https://welltoldgrants.com/grants/par-27-105-national-centers-for-biomedical-imaging-and-bioengineering/), closes not stated