# Research and Training in Complementary and Integrative Health (93.213)

Source: https://welltoldgrants.com/programs/93-213-research-and-training-in-complementary-and-integrative/  
Publisher: Well Told Grants. Data: USAspending.gov and Grants.gov, updated November 7, 2026.

Research and Training in Complementary and Integrative Health is run by Department of Health and Human Services. From fiscal 2021 to 2025 it awarded $575 million in 653 grants, about $880,790 per award.

## Objectives

NCCIH is the lead Federal agency for scientific research on the fundamental science, usefulness, and safety of complementary and integrative treatments and practices. NCCIH seeks to build knowledge across disciplines, focusing on the whole person, and taking a transdisciplinary approach that integrates the natural, social, and health sciences and transcends traditional boundaries. To address the need for objective evidence on the fundamental science, safety and efficacy of complementary and integrative health approaches, NCCIH supports rigorous scientific investigation to better understand how these interventions impact health, for whom, and the optimal methods of practice and delivery. By deepening our scientific understanding of the connections that exist across domains of human health, we can better understand how conditions interrelate, define multicomponent interventions that address these problems, and expand how we support patients through the full continuum of their health experience, including the return to health.
To evaluate complementary and integrative health approaches. The following objectives support this goal: (1) coordinate and facilitate the investigation of complementary and integrative health approaches through peer-reviewed grant solicitations; (2) interface with the NCCIH National Advisory Council; (3) conduct technology assessment conferences for the purpose of establishing areas of Clinical and Pre-clinical research that need to be further developed within complementary health approaches; and (4) maintain a comprehensive bibliographic data base in conjunction with the National Library of Medicine.
The National Center for Complementary and Integrative Health (NCCIH) regularly examines and redefines its research priorities. In setting research priorities, NCCIH considers its existing research portfolio, its 5-year strategic plan, the recommendations of the National Advisory Council for Complementary and Integrative Health, current scientific advances, the plans of other NIH institutes and centers, and input from expert panels and stakeholders. Research constituting a rigorous evidence base for complementary health approaches will be developed through a range of research strategies including basic and translational research, and clinical investigation. Priority setting also takes into account: 1)scientific promise, 2)amenability to rigorous scientific inquiry,3) potential to change health practices, and 4) relationship to use and practice.
Research Approaches
Basic, translational, efficacy/effectiveness, and implementation research for Complementary and Integrative Health approaches need to be studied across the research continuum. NCCIH continues to emphasize basic research that defines biological effects and mechanisms of action; this research is aimed at understanding the nature of complementary health approaches such as their biology, physiology, and physical, chemical and behavioral properties. NCCIH also supports the development of tools, models, and methodologies for studying these approaches. NCCIH continues to encourage efficacy studies to determine specific clinical effects of complementary health approaches under carefully controlled conditions that minimize nonspecific and contextual effects. There is also the need to strengthen translational and preliminary clinical research required to design and implement definitive clinical research and "real world" outcomes and effectiveness research that capitalizes on the reality that many complementary health approaches are in widespread public use.
NCCIH’s support of translational research addresses the need for valid, reliable and relevant research tools, outcome measures, and innovative methodology to enhance the rigor of complementary health approaches within clinical studies and to ensure that they are maximally informative. NCCIH emphasizes studies that inform the design of future trials such as those that will: develop and validate outcome measures; standardize treatment protocols or algorithms; validate treatment algorithms and/or; develop measures of quality control or treatment fidelity; assess effects of various doses or intervention durations; develop preliminary clinical evidence regarding efficacy and safety to support estimates of sample size; or establish feasibility of interventions or study designs in specific populations for future studies.

## Funding by fiscal year

| Year | Amount | Awards |
|---|---|---|
| 2021 | $110 million | 287 |
| 2022 | $113 million | 291 |
| 2023 | $119 million | 318 |
| 2024 | $118 million | 319 |
| 2025 | $115 million | 252 |

## Largest recipients

| Recipient | State | Amount |
|---|---|---|
| Yale Univ | Connecticut | $25.9 million |
| The General Hospital Corporation | Massachusetts | $23.1 million |
| Duke University | North Carolina | $20.0 million |
| The Regents of the University of California, San Francisco | California | $15.2 million |
| Regents of the University of Minnesota | Minnesota | $15.0 million |
| University of California, San Diego | California | $14.8 million |
| University of Washington | Washington | $13.0 million |
| University of Utah | Utah | $12.7 million |
| Regents of the University of Michigan | Michigan | $11.7 million |
| Oregon Health & Science University | Oregon | $11.2 million |
| University of California, Los Angeles | California | $10.8 million |
| Emory University | Georgia | $10.0 million |
| New York University | New York | $10.0 million |
| Beth Israel Deaconess Medical Center, Inc. | Massachusetts | $9.2 million |
| Washington State University | Washington | $8.9 million |
| University of California Irvine | California | $8.8 million |
| Brigham & Womens Hospital Inc | Massachusetts | $8.3 million |
| The Spaulding Rehabilitation Hospital Corporation | Massachusetts | $8.2 million |
| The Rand Corporation | California | $8.0 million |
| The Leland Stanford Junior University | California | $7.9 million |

## Open opportunities

- [NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)](https://welltoldgrants.com/grants/par-25-269-nccih-natural-product-early-phase-clinical-trial-phased/), closes November 13, 2026
- [NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)](https://welltoldgrants.com/grants/par-25-270-nccih-natural-product-early-phase-clinical-trial-award/), closes November 13, 2026
- [NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)](https://welltoldgrants.com/grants/par-25-271-nccih-natural-product-mid-phase-clinical-trial-r01/), closes November 13, 2026
- [NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)](https://welltoldgrants.com/grants/par-25-267-nccih-multi-site-feasibility-clinical-trials-of-mind/), closes November 17, 2026
- [Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)](https://welltoldgrants.com/grants/par-25-268-investigator-initiated-clinical-trials-of-complementary-and/), closes November 17, 2026
- [Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)](https://welltoldgrants.com/grants/par-25-274-feasibility-clinical-trials-of-mind-and-body-interventions/), closes November 17, 2026
- [HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-at-25-003-heal-initiative-pain-research-enhancement-program-prep-r15/), closes November 23, 2026
- [Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-23-317-competing-revisions-to-existing-nih-single-project-research/), closes November 24, 2026
- [NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/rfa-od-24-011-nih-research-software-engineer-rse-award-r50-clinical/), closes December 4, 2026
- [Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-378-intervention-research-to-improve-native-american-health-r34/), closes January 7, 2027
- [HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-25-023-heal-initiative-studies-to-enable-analgesic-discovery-r61/), closes January 15, 2027
- [HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)](https://welltoldgrants.com/grants/rfa-da-28-011-heal-initiative-integrative-management-of-chronic-pain-and/), closes January 26, 2027
- [HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-da-28-012-heal-initiative-integrative-management-of-chronic-pain-and/), closes January 26, 2027
- [Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-24-268-biomedical-research-environment-and-sponsored-programs/), closes January 27, 2027
- [BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-24-031-brain-initiative-preclinical-proof-of-concept-for-novel/), closes January 28, 2027
- [BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-mh-26-170-brain-initiative-development-and-validation-of-novel-tools/), closes February 8, 2027
- [BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-dc-27-004-brain-initiative-exploratory-research-opportunities-using/), closes February 11, 2027
- [NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-100-nih-cdc-and-fda-small-business-innovation-research/), closes April 5, 2027
- [NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-27-102-nih-small-business-technology-transfer-grant-parent-sttr/), closes April 5, 2027
- [Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Clinical Trials Not Allowed)](https://welltoldgrants.com/grants/rfa-od-25-003-short-courses-on-innovative-methodologies-and-approaches-in/), closes April 9, 2027
- [Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-185-mentored-patient-oriented-research-career-development-award/), closes May 7, 2027
- [Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-175-mentored-research-scientist-development-award-parent-k01/), closes May 7, 2027
- [Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-176-mentored-research-scientist-development-award-parent-k01/), closes May 7, 2027
- [NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-194-nih-pathway-to-independence-award-parent-k99-r00/), closes May 7, 2027
- [NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-193-nih-pathway-to-independence-award-parent-k99-r00/), closes May 7, 2027
- [Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-187-midcareer-investigator-award-in-patient-oriented-research/), closes May 7, 2027
- [Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-188-midcareer-investigator-award-in-patient-oriented-research/), closes May 7, 2027
- [Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-184-mentored-patient-oriented-research-career-development-award/), closes May 8, 2027
- [Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)](https://welltoldgrants.com/grants/pa-24-181-mentored-clinical-scientist-research-career-development/), closes May 8, 2027
- [Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-24-182-mentored-clinical-scientist-research-career-development/), closes May 8, 2027
- [Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-211-enhancing-mechanistic-research-on-precision-probiotic/), closes June 2, 2027
- [Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-210-enhancing-mechanistic-research-on-precision-probiotic/), closes June 2, 2027
- [BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-mh-26-120-brain-initiative-reagent-resources-for-brain-cell-type/), closes June 15, 2027
- [BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-mh-26-140-brain-initiative-brain-behavior-quantification-and/), closes June 15, 2027
- [Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-254-change-of-recipient-organization-type-7-parent-clinical/), closes July 12, 2027
- [Successor-in-Interest (Type 6 Parent Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-24-253-successor-in-interest-type-6-parent-clinical-trial/), closes July 17, 2027
- [Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-24-293-blueprint-neurotherapeutics-network-bpn-biologic-based-drug/), closes August 18, 2027
- [NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-080-nih-support-for-conferences-and-scientific-meetings-parent/), closes September 7, 2027
- [BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-27-015-brain-initiative-connectivity-across-scales-brain-connects/), closes October 4, 2027
- [BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-da-27-004-brain-initiative-theories-models-and-methods-for-analysis/), closes November 8, 2027
- [Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-144-dissemination-and-implementation-research-in-health-r01/), closes January 7, 2028
- [Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-143-dissemination-and-implementation-research-in-health-r21/), closes January 7, 2028
- [Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-134-academic-research-enhancement-award-area-for-undergraduate/), closes January 7, 2028
- [Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-298-research-enhancement-award-program-reap-for-health/), closes January 7, 2028
- [NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-304-nih-exploratory-developmental-research-project-grant-parent/), closes January 7, 2028
- [NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)](https://welltoldgrants.com/grants/pa-25-306-nih-exploratory-developmental-research-project-grant-parent/), closes January 7, 2028
- [NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-25-301-nih-research-project-grant-parent-r01-clinical-trial/), closes January 7, 2028
- [NIH Research Project Grant (Parent R01 Clinical Trial Required)](https://welltoldgrants.com/grants/pa-25-305-nih-research-project-grant-parent-r01-clinical-trial/), closes January 7, 2028
- [Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)](https://welltoldgrants.com/grants/par-25-383-blueprint-medtech-translator-ug3-uh3-clinical-trial-optional/), closes January 28, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)](https://welltoldgrants.com/grants/pa-25-168-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 4, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)](https://welltoldgrants.com/grants/pa-25-280-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)](https://welltoldgrants.com/grants/pa-25-423-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)](https://welltoldgrants.com/grants/pa-25-425-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)](https://welltoldgrants.com/grants/pa-25-426-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)](https://welltoldgrants.com/grants/pa-25-422-ruth-l-kirschstein-national-research-service-award-nrsa/), closes May 7, 2028
- [Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)](https://welltoldgrants.com/grants/par-25-449-mind-and-body-interventions-to-restore-whole-person/), closes June 7, 2028
- [BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-27-002-brain-initiative-integrative-team-research-brain-circuits/), closes June 23, 2028
- [Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-076-lasker-clinical-research-scholar-s-program-si2-r00/), closes July 7, 2028
- [Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-25-322-stephen-i-katz-early-stage-investigator-research-project/), closes August 25, 2028
- [Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-001-administrative-supplements-to-existing-nih-grants-and/), closes November 30, 2028
- [BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/rfa-ns-28-010-brain-initiative-research-opportunities-using-invasive/), closes February 8, 2029
- [HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-da-27-016-heal-initiative-translating-addiction-epidemiology/), closes February 9, 2029
- [HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)](https://welltoldgrants.com/grants/rfa-ns-27-007-heal-initiative-non-addictive-analgesic-therapeutics/), closes February 20, 2029
- [Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/pa-27-037-predoctoral-to-postdoctoral-transition-award-parent-f99-k00/), closes April 8, 2029
- [NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)](https://welltoldgrants.com/grants/pa-26-002-nih-collaborative-international-research-project-parent-pf5/), closes May 7, 2029
- [NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)](https://welltoldgrants.com/grants/par-27-077-nih-science-education-partnership-award-sepa-r25-clinical/), closes May 25, 2029
- [Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R33 Clinical Trial Required)](https://welltoldgrants.com/grants/par-28-091-assessing-the-feasibility-of-incorporating-mechanisms-in/), closes November 16, 2029
- [Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-039-small-business-transition-grant-for-new-entrepreneurs-parent/), closes not stated
- [Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)](https://welltoldgrants.com/grants/par-27-040-small-business-transition-grant-for-new-entrepreneurs-parent/), closes not stated
- [Establishing a Research Network to Guide Foundational Research on Human Consciousness](https://welltoldgrants.com/grants/rfa-at-27-002-establishing-a-research-network-to-guide-foundational/), closes not stated
- [Feasibility Studies to Inform the Design of Future Clinical Trials](https://welltoldgrants.com/grants/par-28-011-feasibility-studies-to-inform-the-design-of-future/), closes not stated
- [NIH Pragmatic Trials Conducted in Health Care Systems](https://welltoldgrants.com/grants/par-28-010-nih-pragmatic-trials-conducted-in-health-care-systems/), closes not stated