# Special Projects of Regional and National Significance (93.110)

Source: https://welltoldgrants.com/programs/93-110-special-projects-of-regional-and-national-significance/  
Publisher: Well Told Grants. Data: USAspending.gov and Grants.gov, updated November 7, 2026.

Special Projects of Regional and National Significance is run by Department of Health and Human Services. From fiscal 2021 to 2025 it awarded $1.4 billion in 842 grants, about $1.6 million per award.

## Objectives

The Special Projects of Regional and National Significance Program (SPRANS) carries out maternal and child health (MCH) projects to support training and research; oral health integration; genetic disease testing, counseling, and information development and dissemination programs; newborn screening for sickle cell anemia and other genetic disorders; and comprehensive hemophilia diagnostic and treatment centers. The Supporting Fetal Alcohol Spectrum Disorder (FASD) Screening and Intervention helps reduce alcohol use during pregnancy and improves outcomes for children with FASD nationwide, especially in communities where there is a high rate of binge drinking during pregnancy, including rural areas and medically underserved communities. The program focuses on educating primary care providers and increasing the use of screening, intervention, and referral processes for high-risk pregnancies. The State Maternal Health Innovation program creates state-led maternal health task forces to bring together the voices of key leaders, and pregnant and postpartum individuals using state-specific maternal health data to develop and implement innovative approaches to address the most pressing maternal health needs and disparities. State approaches include strengthening partnerships and collaborations, improving state-level data surveillance on maternal mortality and severe maternal morbidity, and promoting and executing innovation in maternal health service delivery. The MCH Research Portfolio includes the MCH Research Consortium, Maternal Health Research Collaborative for Minority-Serving Institutions, MCH Research Network, and MCH Field-Initiated Innovative Research Studies programs. The research portfolio advances maternal and child health by generating and testing innovative, real-world approaches to improve population-level outcomes. The program addresses critical evidence gaps through the development of research infrastructure and the conduct of rigorous, community-engaged research in close partnership with families and other stakeholders. MCH RNs focus on collaborative, interdisciplinary. The Children’s Safety Network (CSN) purpose is to increase the capacity of Title V agencies to adopt and implement evidence-based child and adolescent safety programs, practices, and policies, with a specific focus on injury and violence-related to Title V performance and outcome measures, such as injury hospitalizations, bullying, safe sleep, and suicide, as well as leading causes of injury-related deaths among children and adolescents (e.g., motor vehicle crashes, firearms, and poisonings).

## Funding by fiscal year

| Year | Amount | Awards |
|---|---|---|
| 2021 | $211 million | 457 |
| 2022 | $260 million | 531 |
| 2023 | $375 million | 580 |
| 2024 | $271 million | 492 |
| 2025 | $258 million | 486 |

## Largest recipients

| Recipient | State | Amount |
|---|---|---|
| Zero to Three National Center for Infants, Toddlers & Families | District of Columbia | $54.3 million |
| University Hospitals Cleveland Medical Center | Ohio | $51.5 million |
| Children's National Medical Center | District of Columbia | $37.2 million |
| University of North Carolina at Chapel Hill | North Carolina | $29.1 million |
| American Academy of Pediatrics | Illinois | $26.4 million |
| University of California, Los Angeles | California | $24.6 million |
| The Johns Hopkins University | Maryland | $21.6 million |
| Michigan Public Health Institute | Michigan | $19.6 million |
| University of Alabama at Birmingham | Alabama | $18.2 million |
| Association of Public Health Laboratories, Inc. (the) | Maryland | $17.5 million |
| Iowa Department of Public Health | Iowa | $17.4 million |
| State of Montana Department of Health and Human Services | Montana | $16.6 million |
| University of Arkansas for Medical Sciences | Arkansas | $16.0 million |
| Acog Foundation | District of Columbia | $15.9 million |
| North Carolina Department of Health & Human Services | North Carolina | $15.7 million |
| The Regents of the University of California, San Francisco | California | $14.7 million |
| University of Illinois | Illinois | $14.0 million |
| Georgetown University | District of Columbia | $13.5 million |
| New Jersey Department of Health | New Jersey | $13.3 million |
| Human Services Vermont Agency of | Vermont | $13.2 million |

## Open opportunities

- [Women's Initiative for Screening and Health (WISH)](https://welltoldgrants.com/grants/hrsa-27-072-women-s-initiative-for-screening-and-health-wish/), closes January 8, 2027
- [Regional Excellence for Access to Comprehensive Care for Hemophilia Networks (REACH Networks)](https://welltoldgrants.com/grants/hrsa-27-037-regional-excellence-for-access-to-comprehensive-care-for/), closes not stated
- [Fetal, Infant, and Child Death Review Program](https://welltoldgrants.com/grants/hrsa-27-031-fetal-infant-and-child-death-review-program/), closes not stated
- [Leadership Education in Adolescent Health (LEAH)](https://welltoldgrants.com/grants/hrsa-27-034-leadership-education-in-adolescent-health-leah/), closes not stated
- [Maternal and Child Health (MCH) Nutrition Training Program](https://welltoldgrants.com/grants/hrsa-27-036-maternal-and-child-health-mch-nutrition-training-program/), closes not stated
- [Healthy Tomorrows Partnership for Children Program (HTPCP)](https://welltoldgrants.com/grants/hrsa-27-033-healthy-tomorrows-partnership-for-children-program-htpcp/), closes not stated
- [Maternal and Child Health Encounters Networks (MCHEK)](https://welltoldgrants.com/grants/hrsa-27-038-maternal-and-child-health-encounters-networks-mchek/), closes not stated
- [Children and Youth with Special Health Care Needs Research Network](https://welltoldgrants.com/grants/hrsa-27-050-children-and-youth-with-special-health-care-needs/), closes not stated
- [Infant-Toddler Court Program–National Resource Center](https://welltoldgrants.com/grants/hrsa-27-020-infant-toddler-court-programnational-resource-center/), closes not stated
- [Infant-Toddler Court Program–State Awards](https://welltoldgrants.com/grants/hrsa-27-021-infant-toddler-court-programstate-awards/), closes not stated