# DoD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award

Source: https://welltoldgrants.com/grants/w81xwh-22-alsrp-tia-dod-amyotrophic-lateral-sclerosis-therapeutic-idea-award/  
Official notice: https://www.grants.gov/search-results-detail/338712

> Defense Health Agency Contracting Activity - DHACA offered grants to any type of organization. It expected to make about 17 awards worth $13.6 million in total. Applications closed on July 28, 2022.

| Field | Value |
|---|---|
| Opportunity number | W81XWH-22-ALSRP-TIA |
| Agency | Defense Health Agency Contracting Activity - DHACA |
| Status | Forecast |
| Deadline | July 28, 2022 |
| Award ceiling | not stated |
| Award floor | not stated |
| Expected awards | 17 |
| Total funding | $13.6 million |
| Cost sharing | not required |
| Assistance Listings | 12.420 |

## Who can apply

- Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

## What the grant funds

The FY22 ALSRP Therapeutic Idea Award (TIA) supports hypothesis-driven therapeutic development and is designed to promote new ideas aimed at drug or treatment discovery that are still in the early stages of development. All research projects should include a well-formulated, testable hypothesis based on strong scientific rationale that holds translational potential to improve ALS treatment and/or advance a novel treatment modality. Preliminary data are not required. While the inclusion of preliminary data is not prohibited, the strength of the application should not rely on preliminary data, but on the innovative approach. Projects that focus primarily on investigating the pathophysiology of ALS, without consideration of therapeutic development, are not within the scope of this funding opportunity. Innovation and impact are important aspects of the Therapeutic Idea Award. Research deemed innovative may introduce a new paradigm, challenge current paradigms, introduce novel concepts or technologies, or exhibit other uniquely creative qualities that may lead to potential therapeutics for ALS. The Therapeutic Idea Award encourages applications submitted by early-career investigators as well as applications that include meaningful and productive collaborations between investigators. Applicants from outside the ALS research field are encouraged to include collaborators with the necessary relevant expertise, such as experience with ALS model systems, endpoints, and pathogenic findings. Biomarker Option: The FY22 ALSRP Therapeutic Idea Award Biomarker Option encourages applicants to include the development of biomarker(s) in parallel with the main proposed Therapeutic Idea Award research effort. Additional funding, as described in Section II.D.5, Funding Restrictions, is being offered for the co-development of biomarkers that will enhance the drug development process. Efforts may include development of target engagement biomarkers, objective pharmacodynamic biomarkers to measure the biological effect of an investigational therapeutic, or predictive/cohort-selective biomarkers that indicate whether a specific therapy will be effective in an individual patient or patient subgroup. Development of markers for the purposes of diagnosis, prognosis, or measurement of disease progression apart from consideration of the therapeutic development process will not be supported.

## Questions people ask

### Is W81XWH-22-ALSRP-TIA still open?

No. It closed on July 28, 2022. A newer notice is open: HT942526BCRPCREA2, closes November 18, 2026 (11 days left).

### Who can apply for DoD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award?

Defense Health Agency Contracting Activity - DHACA accepted applications from any type of organization.

### What is the deadline for DoD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award?

Closed July 28, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

About $13.6 million in total across about 17 awards.

### Who has won Military Medical Research and Development grants before?

The largest recipients over five fiscal years were The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The Univeristy of Texas M.D. Anderson Cancer Center, The Johns Hopkins University. The program made 5,470 awards worth $6.9 billion in that time.