# NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

Source: https://welltoldgrants.com/grants/rfa-rm-27-003-nih-directors-transformative-research-award-for-individual/  
Official notice: https://www.grants.gov/search-results-detail/361084

> National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make about 7 awards worth $8.0 million in total. Applications closed on September 3, 2026.

| Field | Value |
|---|---|
| Opportunity number | RFA-RM-27-003 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | September 3, 2026 |
| Award ceiling | not stated |
| Award floor | not stated |
| Expected awards | 7 |
| Total funding | $8.0 million |
| Cost sharing | not required |
| Assistance Listings | 93.310 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

## What the grant funds

The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

## Questions people ask

### Is RFA-RM-27-003 still open?

No. It closed on September 3, 2026.

### Who can apply for NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)?

Closed September 3, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

About $8.0 million in total across about 7 awards.

### Who has won Trans-NIH Research Support grants before?

The largest recipients over five fiscal years were Duke University, The Leland Stanford Junior University, University of Pittsburgh - of the Commonwealth System of Higher Education. The program made 4,433 awards worth $5.9 billion in that time.