Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure – Clinical Enrollment Hubs

Forecast Expected deadline March 4, 2027 Opportunity RFA-NS-28-004

National Institutes of Health plans to offer grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make about 15 awards. It is a forecast: the notice is expected around January 4, 2027, with applications due around March 4, 2027.

From the official notice on Grants.gov, last changed August 13, 2026. Checked October 31, 2026.

Key dates

Forecast postedAugust 13, 2026
Expected postingJanuary 4, 2027
Expected deadlineMarch 4, 2027
Expected award dateDecember 7, 2027

Add the deadline to your calendar

Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

The National Institute of Neurological Disorders and Stroke (NINDS), in conjunction with The National Heart, Lung and Blood Institute (NHLBI), at the National Institutes of Health (NIH) seek to continue to support the Infrastructure for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The program will encourage applications for network clinical enrollment hubs to support the NIH SIREN clinical trial network. The SIREN Network performs clinical trials that impact the care of individuals with a non-stroke neurological and cardiovascular emergency in the pre-hospital or emergency department setting. The goal of SIREN is to improve the outcomes by identifying effective treatments given in the earliest stages of care. Applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive applications for centers.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to NINDS Department of Emergency Medicine, NINDS_SIREN@ninds.nih.gov, Please contact via e-mail..

Open the official notice

Questions people ask

Who can apply for Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure – Clinical Enrollment Hubs?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure – Clinical Enrollment Hubs?

Expected deadline March 4, 2027. Confirm the date and time in the official notice on Grants.gov.

Similar open grants