# Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks

Source: https://welltoldgrants.com/grants/rfa-mh-27-110-impact-of-immunotherapies-on-cns-outcomes-in-people/  
Official notice: https://www.grants.gov/search-results-detail/361519

> National Institutes of Health plans to offer grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make about 4 awards worth $2.0 million in total. It is a forecast: the notice is expected around August 17, 2026, with applications due around October 22, 2026.

| Field | Value |
|---|---|
| Opportunity number | RFA-MH-27-110 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | expected October 22, 2026 |
| Award ceiling | not stated |
| Award floor | not stated |
| Expected awards | 4 |
| Total funding | $2.0 million |
| Cost sharing | not required |
| Assistance Listings | 93.242 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

## What the grant funds

The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit biphasic research applications to evaluate the impact of HIV immunotherapies on central nervous system (CNS) outcomes in people with HIV and to identify mechanisms, benefits, and risks associated with their use in the CNS compartment. The primary goal is to generate evidence that informs whether HIV immunotherapies can safely and effectively target CNS HIV persistence while minimizing neurotoxicity and neuroinflammation. By addressing CNS-specific barriers such as blood brain barrier penetration, compartmentalized viral dynamics, and immune-mediated effects, this NOFO will support the development of strategies that contribute to sustained virologic remission across anatomical compartments and improve long-term neurologic and cognitive outcomes in people with HIV. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into the impact of HIV immunotherapies on the CNS and viral reservoirs are strongly encouraged to apply to this new NOFO. This NOFO will utilize the R21/R33 activity code.

## Questions people ask

### Who can apply for Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks?

Expected deadline October 22, 2026. Confirm the date and time in the official notice on Grants.gov.

### How much funding is available?

About $2.0 million in total across about 4 awards.