# Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)

Source: https://welltoldgrants.com/grants/rfa-es-27-009-mechanistic-toxicology-of-metals-metal-exposure-transport/  
Official notice: https://www.grants.gov/search-results-detail/363861

> National Institutes of Health plans to offer grants of up to $500,000 (at least $100,000) to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make about 20 awards worth $15.0 million in total. It is a forecast: the notice is expected around December 4, 2026, with applications due around January 5, 2027.

| Field | Value |
|---|---|
| Opportunity number | RFA-ES-27-009 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | expected January 5, 2027 |
| Award ceiling | $500,000 |
| Award floor | $100,000 |
| Expected awards | 20 |
| Total funding | $15.0 million |
| Cost sharing | not required |
| Assistance Listings | 93.113 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

## What the grant funds

The purpose of this funding opportunity is to support mechanistic research to understand how exposure to metals and metal-containing compounds alters biological processes relevant to human health. Of particular interest are studies that elucidate the absorption, distribution, transport, cellular trafficking, biological interactions, and mechanisms of action of metals, including mechanisms through which metals may alter immune homeostasis, cross the placental barrier, or gain access to and affect the central nervous system. Studies may employ experimental models, new approach methodologies, computational approaches, or leverage human biospecimens where these approaches are used to address defined mechanistic hypotheses.

## Questions people ask

### Who can apply for Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)?

Expected deadline January 5, 2027. Confirm the date and time in the official notice on Grants.gov.

### How much funding is available?

Awards of up to $500,000 each. About $15.0 million in total across about 20 awards.