# Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trials Not Allowed)

Source: https://welltoldgrants.com/grants/rfa-es-25-003-time-sensitive-research-opportunities-in-environmental/  
Official notice: https://www.grants.gov/search-results-detail/357465

> National Institutes of Health offered grants of up to $800,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $800,000 in total. Applications closed on December 1, 2025.

| Field | Value |
|---|---|
| Opportunity number | RFA-ES-25-003 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | December 1, 2025 |
| Award ceiling | $800,000 |
| Award floor | not stated |
| Expected awards | not stated |
| Total funding | $800,000 |
| Cost sharing | not required |
| Assistance Listings | 93.113, 93.143 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

## What the grant funds

This Notice of Funding Opportunity (NOFO) is intended to support novel environmental health research in which an unpredictable event or policy change provides a limited window of opportunity to collect human biological samples or environmental exposure data. The primary motivation of the NOFO is to understand the consequences of natural and human-made disasters, emerging environmental public health threats, and policy changes in the U.S. and abroad. A distinguishing feature of an appropriate study is the need for rapid review and funding, substantially shorter than the typical NIH grant review/award cycle, for the research question to be addressed and swiftly implemented. The shortened timeframe will be achieved by more frequent application due dates and expediting peer review, council concurrence and award issuance. The entire cycle, from submission to award, is expected to be within 4-6 months.

## Questions people ask

### Is RFA-ES-25-003 still open?

No. It closed on December 1, 2025.

### Who can apply for Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trials Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trials Not Allowed)?

Closed December 1, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

Awards of up to $800,000 each. About $800,000 in total.

### Who has been funded under RFA-ES-25-003?

NIH RePORTER lists 6 projects funded under RFA-ES-25-003 in fiscal 2025 to 2026, at 5 institutions. The most were at University of California Los Angeles, Arizona State University-Tempe Campus, University of Louisville.

### Who has won Environmental Health grants before?

The largest recipients over five fiscal years were Icahn School of Medicine at Mount Sinai, The Trustees of Columbia University in the City of New York, University of North Carolina at Chapel Hill. The program made 1,980 awards worth $2.1 billion in that time.