# Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2

Source: https://welltoldgrants.com/grants/rfa-da-28-001-single-cell-opioid-responses-in-the-context-of/  
Official notice: https://www.grants.gov/search-results-detail/363680

> National Institutes of Health plans to offer grants of up to $1.0 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make about 8 awards worth $5.0 million in total. It is a forecast: the notice is expected around February 1, 2027, with applications due around June 8, 2027.

| Field | Value |
|---|---|
| Opportunity number | RFA-DA-28-001 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | expected June 8, 2027 |
| Award ceiling | $1.0 million |
| Award floor | not stated |
| Expected awards | 8 |
| Total funding | $5.0 million |
| Cost sharing | not required |
| Assistance Listings | 93.279 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

## What the grant funds

NIDA seeks to further advance its mission in the area of single cell biology. Since 2020, the NIDA-funded Single Cell Opioid Responses in the Context of HIV (SCORCH) consortium has generated single-nucleus datasets from human and animal postmortem brain tissue under conditions of HIV infection, antiretroviral therapy (ART), and/or substance exposure (e.g. opioids, cocaine, methamphetamine, and cannabinoids). Building on this Phase 1 foundation, NIDA will encourage research addressing critical questions on Substance Use Disorder (SUD) and interactions with HIV disease progression at the subcellular, cellular, or circuit levels in the Central Nervous System (CNS). Many new cutting-edge single cell approaches (e.g. interrogation of RNA splicing, non-coding RNAs, epigenomic or proteomic features, subcellular or synaptic localization and function, spatial interactions, cell-cell communication, or cellular connectivity) now enable novel hypothesis-generating studies. Along with data mining studies to identify candidate mechanisms or targets contributing to HIV/SUD interactions and hypothesis-driven studies to assess functional significance, we expect SCORCH Phase 2 to significantly advance our mechanistic understanding of SUDs and HIV in the CNS and identify targets for novel therapies. Grant authorities that allow NIDA to forecast this opportunity are 42 U.S.C. §§ 241 and 284

## Questions people ask

### Who can apply for Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2?

Expected deadline June 8, 2027. Confirm the date and time in the official notice on Grants.gov.

### How much funding is available?

Awards of up to $1.0 million each. About $5.0 million in total across about 8 awards.