# NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System

Source: https://welltoldgrants.com/grants/rfa-da-27-012-nih-blueprint-initiative-tools-for-germline-gene-editing/  
Official notice: https://www.grants.gov/search-results-detail/362313

> National Institutes of Health plans to offer grants of up to $1.2 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make about 4 awards worth $7.2 million in total. It is a forecast: the notice is expected around August 10, 2026, with applications due around October 12, 2026.

| Field | Value |
|---|---|
| Opportunity number | RFA-DA-27-012 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | expected October 12, 2026 |
| Award ceiling | $1.2 million |
| Award floor | not stated |
| Expected awards | 4 |
| Total funding | $7.2 million |
| Cost sharing | not required |
| Assistance Listings | 93.279 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

## What the grant funds

The NIH Blueprint (a consortium of NIH Institutes that support neuroscience research) seeks to advance its mission by supporting the development, optimization, validation, and application of germline and somatic transgenic and gene-editing approaches in experimental systems modeling key features of human brain anatomy, circuitry, cognition, behavior, and lifespan. This initiative will build on the previously supported marmoset gene-editing infrastructure, by integrating New Approach Methodologies (NAMs) with other models, to advance understanding of human brain function and disease, including human-derived NAMs for cross-species comparisons across development. Many mechanisms of complex conditions, such as autism spectrum disorders, schizophrenia, and other behavioral/developmental disorders, cannot yet be captured in NAMs and are therefore high priorities for research investment to accelerate development and validation of human-derived NAMs. Appropriate models should be used and clearly justified as necessary for questions involving neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping related to human brain disease and function. Grant authorities are as follows: 42 U.S.C 241 and 284.

## Questions people ask

### Who can apply for NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System?

Expected deadline October 12, 2026. Confirm the date and time in the official notice on Grants.gov.

### How much funding is available?

Awards of up to $1.2 million each. About $7.2 million in total across about 4 awards.